Nocebo response in dentistry: A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal

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Watanabe, TakeshiAarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, Tokushima, Japan.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan. (author)

Nocebo response in dentistry : A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal

Article/chapterEnglish2023

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2023-01-24
John Wiley & Sons,2023
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:mau-58365
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-58365URI
https://doi.org/10.1111/joor.13414DOI

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Language:English
Summary in:English

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Subject category:for swepub-publicationtype

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BackgroundThe nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments. ObjectiveThis meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery. MethodsA systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE >= 1) separately for the active and placebo arms. The proportion of patients with AE >= 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated. ResultsIn 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE >= 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE >= 1 and drug-related dropouts. ConclusionThese results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
analgesics
long term adverse effects
nocebo effect
oral surgery
pain
third molar

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Sieg, MetteAarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (author)
Lunde, Sigrid JuhlAarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (author)
Persson, MadsAarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (author)
Taneja, PankajAarhus Univ, Dept Dent & Oral Hlth, Sect Oral & Maxillofacial Surg & Oral Pathol, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden. (author)
Baad-Hansen, LeneScandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden.;Aarhus Univ, Dept Dent & Oral Hlth, Sect Orofacial Pain & Jaw Funct, Aarhus, Denmark. (author)
Pigg, MariaMalmö universitet,Odontologiska fakulteten (OD),Foresight,Scandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden.(Swepub:mau)odmapi (author)
Vase, LeneAarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (author)
Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, Tokushima, Japan.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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By the university: Malmö University

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