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Developing a core o...
Developing a core outcome set for future infertility research: an international consensus development study
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Duffy, J. M. N. (author)
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AlAhwany, H. (author)
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Bhattacharya, S. (author)
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Collura, B. (author)
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Curtis, C. (author)
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Evers, J. L. H. (author)
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Farquharson, R. G. (author)
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Franik, S. (author)
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Giudice, L. C. (author)
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Khalaf, Y. (author)
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Knijnenburg, J. M. L. (author)
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Leeners, B. (author)
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Legro, R. S. (author)
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Lensen, S. (author)
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Vazquez-Niebla, J. C. (author)
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Mavrelos, D. (author)
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Mol, B. W. J. (author)
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Niederberger, C. (author)
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Ng, E. H. Y. (author)
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Otter, A. S. (author)
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Puscasiu, L. (author)
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Rautakallio-Hokkanen, S. (author)
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Repping, S. (author)
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Sarris, I. (author)
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Simpson, J. L. (author)
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- Strandell, Annika, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Strawbridge, C. (author)
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Torrance, H. L. (author)
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Vail, A. (author)
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van Wely, M. (author)
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Vercoe, M. A. (author)
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Vuong, N. L. (author)
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Wang, A. Y. (author)
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Wang, R. (author)
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Wilkinson, J. (author)
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Youssef, M. A. (author)
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Farquhar, C. M. (author)
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(creator_code:org_t)
- 2020-11-30
- 2020
- English.
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In: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 35:12, s. 2725-2734
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- STUDY QUESTION: Can a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed? SUMMARY ANSWER: A minimum data set, known as a core outcome set, has been developed for randomized controlled trials (RCTs) and systematic reviews evaluating potential treatments for infertility. WHAT IS KNOWN ALREADY: Complex issues, including a failure to consider the perspectives of people with fertility problems when selecting outcomes, variations in outcome definitions and the selective reporting of outcomes on the basis of statistical analysis, make the results of infertility research difficult to interpret. STUDY DESIGN, SIZE, DURATION: A three-round Delphi survey (372 participants from 41 countries) and consensus development workshop (30 participants from 27 countries). PARTICIPANTS/MATERIALS, SETTING, METHODS: Healthcare professionals, researchers and people with fertility problems were brought together in an open and transparent process using formal consensus science methods. MAIN RESULTS AND THE ROLE OF CHANCE: The core outcome set consists of: viable intrauterine pregnancy confirmed by ultrasound (accounting for singleton, twin and higher multiple pregnancy); pregnancy loss (accounting for ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy); live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital anomaly. Time to pregnancy leading to live birth should be reported when applicable. LIMITATIONS, REASONS FOR CAUTION: We used consensus development methods which have inherent limitations, including the representativeness of the participant sample, Delphi survey attrition and an arbitrary consensus threshold. WIDER IMPLICATIONS OF THE FINDINGS: Embedding the core outcome set within RCTs and systematic reviews should ensure the comprehensive selection, collection and reporting of core outcomes. Research funding bodies, the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) statement, and over 80 specialty journals, including the Cochrane Gynaecology and Fertility Group, Fertility and Sterility and Human Reproduction, have committed to implementing this core outcome set.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Consensus development study
- core outcome sets
- modified Delphi method
- modified Nominal Group Technique
- outcome measures
- outcomes
- clinical-trials
- protocol
- Obstetrics & Gynecology
- Reproductive Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Duffy, J. M. N.
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AlAhwany, H.
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Bhattacharya, S.
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Collura, B.
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Curtis, C.
-
Evers, J. L. H.
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show more...
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Farquharson, R. ...
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Franik, S.
-
Giudice, L. C.
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Khalaf, Y.
-
Knijnenburg, J. ...
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Leeners, B.
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Legro, R. S.
-
Lensen, S.
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Vazquez-Niebla, ...
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Mavrelos, D.
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Mol, B. W. J.
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Niederberger, C.
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Ng, E. H. Y.
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Otter, A. S.
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Puscasiu, L.
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Rautakallio-Hokk ...
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Repping, S.
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Sarris, I.
-
Simpson, J. L.
-
Strandell, Annik ...
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Strawbridge, C.
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Torrance, H. L.
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Vail, A.
-
van Wely, M.
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Vercoe, M. A.
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Vuong, N. L.
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Wang, A. Y.
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Wang, R.
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Wilkinson, J.
-
Youssef, M. A.
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Farquhar, C. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Human Reproducti ...
- By the university
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University of Gothenburg