Sökning: WFRF:(Mebius Reina E) > Chemokine CXCL13 is...
Fältnamn | Indikatorer | Metadata |
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000 | 03121naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:6706bf18-07fb-47c7-86f7-22145ffd35b4 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/15060082 URI |
024 | 7 | a https://doi.org/10.1038/ni.17892 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a van de Pavert, Serge A.4 aut |
245 | 1 0 | a Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation |
264 | c 2009-09-27 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
520 | a The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
700 | 1 | a Olivier, Brenda J.4 aut |
700 | 1 | a Goverse, Gera4 aut |
700 | 1 | a Vondenhoff, Mark F.4 aut |
700 | 1 | a Greuter, Mascha4 aut |
700 | 1 | a Beke, Patrick4 aut |
700 | 1 | a Kusser, Kim4 aut |
700 | 1 | a Hoepken, Uta E.4 aut |
700 | 1 | a Lipp, Martin4 aut |
700 | 1 | a Niederreither, Karen4 aut |
700 | 1 | a Blomhoff, Rune4 aut |
700 | 1 | a Sitnik, Katarzynau Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups4 aut0 (Swepub:lu)ka1557si |
700 | 1 | a Agace, Williamu Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups4 aut0 (Swepub:lu)immu-wag |
700 | 1 | a Randall, Troy D.4 aut |
700 | 1 | a de Jonge, Wouter J.4 aut |
700 | 1 | a Mebius, Reina E.4 aut |
710 | 2 | a Immunologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Immunologyd : Springer Science and Business Media LLCg 10:11, s. 78-1193q 10:11<78-1193x 1529-2908x 1529-2916 |
856 | 4 | u http://dx.doi.org/10.1038/ni.1789y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc2771164?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/1506008 |
856 | 4 8 | u https://doi.org/10.1038/ni.1789 |
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