WFRF:(Motiño O)
Sökning: WFRF:(Motiño O) > ACBP/DBI protein ne...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03462naa a2200565 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:236191214 | |
| 003 | SwePub | |
| 008 | 240124s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:152471169 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2361912142 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.22073441192 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1524711692 URI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Motiño, O4 aut |
| 245 | 1 0 | a ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis |
| 264 | c 2022-10-03 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2022 |
| 506 | a gratis | |
| 520 | a Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. α-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of α-DBI were mimicked by the induction of ACBP/DBI-specific autoantibodies, an inducibleAcbp/Dbiknockout or a constitutiveGabrg2F77Imutation that abolishes ACBP/DBI binding to the GABAAreceptor. Liver-protective α-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout ofAtg4b. Of note, α-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults. | |
| 700 | 1 | a Lambertucci, F4 aut |
| 700 | 1 | a Anagnostopoulos, G4 aut |
| 700 | 1 | a Li, S4 aut |
| 700 | 1 | a Nah, J4 aut |
| 700 | 1 | a Castoldi, F4 aut |
| 700 | 1 | a Senovilla, L4 aut |
| 700 | 1 | a Montégut, L4 aut |
| 700 | 1 | a Chen, H4 aut |
| 700 | 1 | a Durand, S4 aut |
| 700 | 1 | a Bourgin, M4 aut |
| 700 | 1 | a Aprahamian, F4 aut |
| 700 | 1 | a Nirmalathasan, N4 aut |
| 700 | 1 | a Alvarez-Valadez, K4 aut |
| 700 | 1 | a Sauvat, A4 aut |
| 700 | 1 | a Carbonnier, V4 aut |
| 700 | 1 | a Djavaheri-Mergny, M4 aut |
| 700 | 1 | a Pietrocola, Fu Karolinska Institutet4 aut |
| 700 | 1 | a Sadoshima, J4 aut |
| 700 | 1 | a Maiuri, MC4 aut |
| 700 | 1 | a Martins, I4 aut |
| 700 | 1 | a Kroemer, G4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 119:41, s. e2207344119-q 119:41<e2207344119-x 1091-6490 |
| 773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 119:41, s. e2207344119-q 119:41<e2207344119-x 0027-8424 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236191214 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.2207344119 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152471169 |
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