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Coronary Plaque in ...
Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations
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- Karady, Julia (author)
- Semmelweis University,Massachusetts General Hospital
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- Lu, Michael T. (author)
- Massachusetts General Hospital
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- Bergström, Göran (author)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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- Mayrhofer, Thomas (author)
- Massachusetts General Hospital,University of Applied Sciences Stralsund
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- Taron, Jana (author)
- University Medical Center Freiburg,Massachusetts General Hospital
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- Foldyna, Borek (author)
- Massachusetts General Hospital
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- Paradis, Kayla (author)
- Massachusetts General Hospital
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- McCallum, Sara (author)
- Massachusetts General Hospital
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- Aberg, Judith A. (author)
- Icahn School of Medicine at Mount Sinai
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- Currier, Judith S. (author)
- University of California, Los Angeles
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- Fitch, Kathleen V. (author)
- Massachusetts General Hospital
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- Fulda, Evelynne S. (author)
- Massachusetts General Hospital
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- Bloomfield, Gerald S. (author)
- Duke Clinical Research Institute (DCRI)
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Overton, Edgar T. (author)
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- Lind, Lars (author)
- Uppsala University
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- Östgren, Carl Johan (author)
- Linköping University
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- Elvstam, Olof (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Växjö Central Hospital
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- Söderberg, Stefan (author)
- Umeå University
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- Jernberg, Tomas (author)
- Danderyd Hospital
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- Pepe, Rosalie (author)
- Cooper University Hospital, Camden
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- Dubé, Michael P. (author)
- University of Southern California
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- Mushatt, David (author)
- Tulane University School of Medicine
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- Fichtenbaum, Carl J. (author)
- University of Cincinnati
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- Malvestutto, Carlos (author)
- Ohio State University
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- Zanni, Markella V. (author)
- Massachusetts General Hospital
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- Hoffmann, Udo (author)
- Massachusetts General Hospital
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Ribaudo, Heather (author)
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- Grinspoon, Steven K. (author)
- Massachusetts General Hospital
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- Douglas, Pamela S. (author)
- Duke Clinical Research Institute (DCRI)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: JACC: Advances. - 2772-963X. ; 3:6
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known HIV (PwoH) needs clarification. Objectives: The purpose of this study was to determine coronary plaque burden/phenotype in PWH vs PwoH. Methods: Nonstatin using participants from 3 contemporary populations without known coronary plaques with coronary CT were compared: the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) studying PWH without cardiovascular symptoms at low-to-moderate risk (n = 755); the SCAPIS (Swedish Cardiopulmonary Bioimage Study) of asymptomatic community PwoH at low-to-intermediate cardiovascular risk (n = 23,558); and the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) of stable chest pain PwoH (n = 2,291). The coronary plaque prevalence on coronary CT was compared, and comparisons were stratified by 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and coronary artery calcium (CAC) presence. Results: Compared to SCAPIS and PROMISE PwoH, REPRIEVE PWH were younger (50.8 ± 5.8 vs 57.3 ± 4.3 and 60.0 ± 8.0 years; P < 0.001) and had lower ASCVD risk (5.0% ± 3.2% vs 6.0% ± 5.3% and 13.5% ± 11.0%; P < 0.001). More PWH had plaque compared to the asymptomatic cohort (48.5% vs 40.3%; P < 0.001). When stratified by ASCVD risk, PWH had more plaque compared to SCAPIS and a similar prevalence of plaque compared to PROMISE. CAC = 0 was more prevalent in PWH (REPRIEVE 65.2%; SCAPIS 61.6%; PROMISE 49.6%); among CAC = 0, plaque was more prevalent in PWH compared to the PwoH cohorts (REPRIEVE 20.8%; SCAPIS 5.4%; PROMISE 12.3%, P < 0.001). Conclusions: Asymptomatic PWH in REPRIEVE had more plaque than asymptomatic PwoH in SCAPIS but had similar prevalence to a higher-risk stable chest pain cohort in PROMISE. In PWH, CAC = 0 does not reliably exclude plaque.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- asymptomatic community cohort
- cardiovascular disease
- coronary CT angiography
- coronary plaque
- people with HIV
- stable chest pain
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Karady, Julia
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Lu, Michael T.
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Bergström, Göran
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Mayrhofer, Thoma ...
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Taron, Jana
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Foldyna, Borek
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show more...
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Paradis, Kayla
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McCallum, Sara
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Aberg, Judith A.
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Currier, Judith ...
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Fitch, Kathleen ...
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Fulda, Evelynne ...
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Bloomfield, Gera ...
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Overton, Edgar T ...
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Lind, Lars
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Östgren, Carl Jo ...
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Elvstam, Olof
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Söderberg, Stefa ...
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Jernberg, Tomas
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Pepe, Rosalie
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Dubé, Michael P.
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Mushatt, David
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Fichtenbaum, Car ...
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Malvestutto, Car ...
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Zanni, Markella ...
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Hoffmann, Udo
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Ribaudo, Heather
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Grinspoon, Steve ...
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Douglas, Pamela ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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JACC: Advances
- By the university
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Lund University