WFRF:(Neerincx M)
Sökning: WFRF:(Neerincx M) > Epigenome-Wide Asso...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03526naa a2200589 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:152378619 | |
| 003 | SwePub | |
| 008 | 240701s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1523786192 URI |
| 024 | 7 | a https://doi.org/10.3390/biomedicines110306762 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Martin-Almeida, M4 aut |
| 245 | 1 0 | a Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma |
| 264 | c 2023-02-23 | |
| 264 | 1 | b MDPI AG,c 2023 |
| 520 | a Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated. This study aims to identify DNAm markers in whole blood associated either with BDR or FeNO in pediatric asthma. We analyzed 121 samples from children with moderate-to-severe asthma. The association of genome-wide DNAm with BDR and FeNO has been assessed using regression models, adjusting for age, sex, ancestry, and tissue heterogeneity. Cross-tissue validation was assessed in 50 nasal samples. Differentially methylated regions (DMRs) and enrichment in traits and biological pathways were assessed. A false discovery rate (FDR) < 0.1 and a genome-wide significance threshold of p < 9 × 10−8 were used to control for false-positive results. The CpG cg12835256 (PLA2G12A) was genome-wide associated with FeNO in blood samples (coefficient= −0.015, p = 2.53 × 10−9) and nominally associated in nasal samples (coefficient = −0.015, p = 0.045). Additionally, three CpGs were suggestively associated with BDR (FDR < 0.1). We identified 12 and four DMRs associated with FeNO and BDR (FDR < 0.05), respectively. An enrichment in allergic and inflammatory processes, smoking, and aging was observed. We reported novel associations of DNAm markers associated with BDR and FeNO enriched in asthma-related processes. | |
| 700 | 1 | a Perez-Garcia, J4 aut |
| 700 | 1 | a Herrera-Luis, E4 aut |
| 700 | 1 | a Rosa-Baez, C4 aut |
| 700 | 1 | a Gorenjak, M4 aut |
| 700 | 1 | a Neerincx, AH4 aut |
| 700 | 1 | a Sardon-Prado, O4 aut |
| 700 | 1 | a Toncheva, AA4 aut |
| 700 | 1 | a Harner, S4 aut |
| 700 | 1 | a Wolff, C4 aut |
| 700 | 1 | a Brandstetter, S4 aut |
| 700 | 1 | a Valletta, E4 aut |
| 700 | 1 | a Abdel-Aziz, MI4 aut |
| 700 | 1 | a Hashimoto, S4 aut |
| 700 | 1 | a Berce, V4 aut |
| 700 | 1 | a Corcuera-Elosegui, P4 aut |
| 700 | 1 | a Korta-Murua, J4 aut |
| 700 | 1 | a Buntrock-Dopke, H4 aut |
| 700 | 1 | a Vijverberg, SJH4 aut |
| 700 | 1 | a Verster, JC4 aut |
| 700 | 1 | a Kerssemakers, N4 aut |
| 700 | 1 | a Hedman, AMu Karolinska Institutet4 aut |
| 700 | 1 | a Almqvist, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Villar, J4 aut |
| 700 | 1 | a Kraneveld, AD4 aut |
| 700 | 1 | a Potocnik, U4 aut |
| 700 | 1 | a Kabesch, M4 aut |
| 700 | 1 | a Maitland-van der Zee, AH4 aut |
| 700 | 1 | a Pino-Yanes, M4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Biomedicinesd : MDPI AGg 11:3q 11:3x 2227-9059 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152378619 |
| 856 | 4 8 | u https://doi.org/10.3390/biomedicines11030676 |
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- Av författaren/redakt...
- Martin-Almeida, ...
- Perez-Garcia, J
- Herrera-Luis, E
- Rosa-Baez, C
- Gorenjak, M
- Neerincx, AH
- visa fler...
- Sardon-Prado, O
- Toncheva, AA
- Harner, S
- Wolff, C
- Brandstetter, S
- Valletta, E
- Abdel-Aziz, MI
- Hashimoto, S
- Berce, V
- Corcuera-Elosegu ...
- Korta-Murua, J
- Buntrock-Dopke, ...
- Vijverberg, SJH
- Verster, JC
- Kerssemakers, N
- Hedman, AM
- Almqvist, C
- Villar, J
- Kraneveld, AD
- Potocnik, U
- Kabesch, M
- Maitland-van der ...
- Pino-Yanes, M
- visa färre...
- Artiklar i publikationen
- Biomedicines
- Av lärosätet
- Karolinska Institutet
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