New light shed on the early evolution of  limb-bone growth plate and bone marrow

Lopez, Jordi Estefa (författare): Uppsala universitet,Evolution och utvecklingsbiologi

Tafforeau, Paul (författare): European Synchrotron Radiat Facil, Grenoble, France

Clement, Alice (författare): Flinders Univ S Australia, Coll Sci & Engn, Adelaide, SA, Australia

Klembara, Jozef (författare): Comenius Univ, Fac Nat Sci, Dept Ecol, Bratislava, Slovakia

Niedzwiedzki, Grzegorz, 1980- (författare): Uppsala universitet,Evolution och utvecklingsbiologi

Berruyer, Camille (författare): European Synchrotron Radiat Facil, Grenoble, France

Sanchez, Sophie (författare): Uppsala universitet,Evolution och utvecklingsbiologi,European Synchrotron Radiat Facil, Grenoble, France

(creator_code:org_t)

Relaterad länk:: https://doi.org/10.7...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.7...; visa färre...

Abstract Ämnesord

Stäng

The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent from the fin bones of ray-finned fish. When did long bones start producing blood cells? Recent hypotheses suggested that haematopoiesis migrated into long bones prior to the water-to-land transition and protected newly-produced blood cells from harsher environmental conditions. However little fossil evidence to support these hypotheses has been provided so far. Observations of the humeral microarchitecture of stem-tetrapods, batrachians and amniotes were performed using classical sectioning and three-dimensional synchrotron virtual histology. They show that Permian tetrapods seem to be among the first to exhibit a centralised marrow organisation which allows haematopoiesis as in extant amniotes. Not only does our study demonstrate that long-bone haematopoiesis was probably not an exaptation to the water-to-land transition but it sheds light on the early evolution of limb-bone development and the sequence of bone-marrow functional acquisitions.

Av författaren/redakt...: Lopez, Jordi Est ...; Tafforeau, Paul; Clement, Alice; Klembara, Jozef; Niedzwiedzki, Gr ...; Berruyer, Camill ...; visa fler...; Sanchez, Sophie; visa färre...

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