Sökning: WFRF:(Nieves Colón Maria A.) > Disentangling Signa...
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000 | 04675naa a2200757 4500 | |
001 | oai:DiVA.org:su-204383 | |
003 | SwePub | |
008 | 220504s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2043832 URI |
024 | 7 | a https://doi.org/10.1093/molbev/msac0762 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mendoza-Revilla, Javier4 aut |
245 | 1 0 | a Disentangling Signatures of Selection Before and After European Colonization in Latin Americans |
264 | c 2022-04-19 | |
264 | 1 | b Oxford University Press (OUP),c 2022 |
338 | a print2 rdacarrier | |
520 | a Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of ∼4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
653 | a natural selection | |
653 | a Latin Americans | |
653 | a Native Americans | |
653 | a admixture | |
700 | 1 | a Chacón-Duque, J. Camilou Stockholms universitet,Institutionen för arkeologi och antikens kultur4 aut0 (Swepub:su)cach0137 |
700 | 1 | a Fuentes-Guajardo, Macarena4 aut |
700 | 1 | a Ormond, Louise4 aut |
700 | 1 | a Wang, Ke4 aut |
700 | 1 | a Hurtado, Malena4 aut |
700 | 1 | a Villegas, Valeria4 aut |
700 | 1 | a Granja, Vanessa4 aut |
700 | 1 | a Acuña-Alonzo, Victor4 aut |
700 | 1 | a Jaramillo, Claudia4 aut |
700 | 1 | a Arias, William4 aut |
700 | 1 | a Barquera, Rodrigo4 aut |
700 | 1 | a Gómez-Valdés, Jorge4 aut |
700 | 1 | a Villamil-Ramírez, Hugo4 aut |
700 | 1 | a de Cerqueira, Caio C. Silva4 aut |
700 | 1 | a Rivera, Keyla M. Badillo4 aut |
700 | 1 | a Nieves-Colón, Maria A.4 aut |
700 | 1 | a Gignoux, Christopher R.4 aut |
700 | 1 | a Wojcik, Genevieve L.4 aut |
700 | 1 | a Moreno-Estrada, Andrés4 aut |
700 | 1 | a Hünemeier, Tábita4 aut |
700 | 1 | a Ramallo, Virginia4 aut |
700 | 1 | a Schuler-Faccini, Lavinia4 aut |
700 | 1 | a Gonzalez-José, Rolando4 aut |
700 | 1 | a Bortolini, Maria-Cátira4 aut |
700 | 1 | a Canizales-Quinteros, Samuel4 aut |
700 | 1 | a Gallo, Carla4 aut |
700 | 1 | a Poletti, Giovanni4 aut |
700 | 1 | a Bedoya, Gabriel4 aut |
700 | 1 | a Rothhammer, Francisco4 aut |
700 | 1 | a Balding, David4 aut |
700 | 1 | a Fumagalli, Matteo4 aut |
700 | 1 | a Adhikari, Kaustubh4 aut |
700 | 1 | a Ruiz-Linares, Andrés4 aut |
700 | 1 | a Hellenthal, Garrett4 aut |
710 | 2 | a Stockholms universitetb Institutionen för arkeologi och antikens kultur4 org |
773 | 0 | t Molecular biology and evolutiond : Oxford University Press (OUP)g 39:4q 39:4x 0737-4038x 1537-1719 |
856 | 4 | u https://doi.org/10.1093/molbev/msac076y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-204383 |
856 | 4 8 | u https://doi.org/10.1093/molbev/msac076 |
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