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Sökning: WFRF:(Nilsson Kerstin 1953 ) > (2010-2014) > Androgen levels dur...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005124naa a2200481 4500
001oai:DiVA.org:oru-33753
003SwePub
008140214s2014 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-214588
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-337532 URI
0247 a https://doi.org/10.3109/13697137.2013.8000392 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2145882 URI
040 a (SwePub)orud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Baumgart, Juliane,d 1978-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Obstetrics and Gynecology, Örebro University Hospital, Sweden4 aut0 (Swepub:oru)jebt
2451 0a Androgen levels during adjuvant endocrine therapy in postmenopausal breast cancer patients
264 c 2013-06-28
264 1a London, United Kingdom :b Informa Healthcare,c 2014
338 a print2 rdacarrier
500 a Funding Agencies:Uppsala-Örebro Regional Research Council  Swedish Cancer SocietyLions Clubs International  Percy Falk Foundation 
520 a Objective: To investigate plasma steroid hormone levels in postmenopausal breast cancer patients with and without adjuvant endocrine therapy and in healthy postmenopausal women.Methods: Steroid hormone levels in postmenopausal breast cancer patients treated with aromatase inhibitors (n = 32) were compared with breast cancer patients treated with tamoxifen (n = 34), breast cancer patients without adjuvant endocrine therapy (n = 15), and healthy postmenopausal women (n = 56). Pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone (DHEA), androstenedione, total testosterone, dihydrotestosterone, estrone and estradiol were measured using liquid chromatography-tandem mass spectrometry. Sex hormone binding globulin was measured by solid-phase chemiluminescent immunometric assays, and the free androgen index was calculated.Results: Aromatase inhibitor users did not differ in dihydrotestosterone, total testosterone, androstenedione, DHEA, or free androgen index levels from healthy controls or untreated breast cancer patients. The highest total testosterone levels were found in tamoxifen-treated women, who had significantly higher plasma concentrations than both women treated with aromatase inhibitors and breast cancer patients without adjuvant treatment. Concentrations of cortisol and cortisone were significantly greater in aromatase inhibitor users as well as tamoxifen users, in comparison with healthy controls and untreated breast cancer patients. Aromatase inhibitor users had lower estrone and estradiol plasma concentrations than all other groups.Conclusion: Adjuvant treatment with aromatase inhibitors or tamoxifen was associated with increased cortisol and cortisone plasma concentrations as well as decreased estradiol concentrations. Androgen levels were elevated in tamoxifen-treated women but not in aromatase inhibitor users.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653 a Breast cancer
653 a steroid hormones
653 a LC-MS/MS
653 a aromatase inhibitors
653 a tamoxifen
653 a postmenopausal women
7001 a Nilsson, Kerstin,d 1953-u Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Department of Obstetrics and Gynecology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)ktnn
7001 a Stavreus Evers, Anneliu Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/olovsson4 aut0 (Swepub:uu)annst384
7001 a Kallak, Theodora Kunovac,d 1985-u Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)theka349
7001 a Kushnir, M. M.u Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA4 aut
7001 a Bergquist, Jonasu Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA4 aut0 (Swepub:uu)jbe25356
7001 a Sundström Poromaa, Inger,d 1964-u Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa4 aut0 (Swepub:uu)inspo702
7102 a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org
7730 t Climactericd London, United Kingdom : Informa Healthcareg 17:1, s. 48-54q 17:1<48-54x 1369-7137x 1473-0804
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33753
8564 8u https://doi.org/10.3109/13697137.2013.800039
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-214588

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