WFRF:(Ninchoji Takeshi)
Search: WFRF:(Ninchoji Takeshi) > (2021) > Paladin is a phosph...
- 2 of 2
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04919naa a2200553 4500 | |
| 001 | oai:DiVA.org:uu-438815 | |
| 003 | SwePub | |
| 008 | 210412s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4388152 URI |
| 024 | 7 | a https://doi.org/10.15252/embr.2020502182 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nitzsche, Anja,d 1985-u Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anjni376 |
| 245 | 1 0 | a Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis |
| 264 | c 2020-12-28 | |
| 264 | 1 | b EMBO Press,c 2021 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Shared first authorship: Anja Nitzsche, Riikka Pietilä and Dominic T Love | |
| 520 | a Cell signalling governs cellular behaviour and is therefore subject to tight spatiotemporal regulation. Signalling output is modulated by specialized cell membranes and vesicles which contain unique combinations of lipids and proteins. The phosphatidylinositol 4,5-bisphosphate (PI(4,5)P-2), an important component of the plasma membrane as well as other subcellular membranes, is involved in multiple processes, including signalling. However, which enzymes control the turnover of non-plasma membrane PI(4,5)P-2, and their impact on cell signalling and function at the organismal level are unknown. Here, we identify Paladin as a vascular PI(4,5)P-2 phosphatase regulating VEGFR2 endosomal signalling and angiogenesis. Paladin is localized to endosomal and Golgi compartments and interacts with vascular endothelial growth factor receptor 2 (VEGFR2) in vitro and in vivo. Loss of Paladin results in increased internalization of VEGFR2, over-activation of extracellular regulated kinase 1/2, and hypersprouting of endothelial cells in the developing retina of mice. These findings suggest that inhibition of Paladin, or other endosomal PI(4,5)P-2 phosphatases, could be exploited to modulate VEGFR2 signalling and angiogenesis, when direct and full inhibition of the receptor is undesirable. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a endocytosis | |
| 653 | a Paladin | |
| 653 | a phosphatase | |
| 653 | a phosphoinositide | |
| 653 | a VEGFR2 | |
| 700 | 1 | a Pietilä, Riikkau Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)riipi666 |
| 700 | 1 | a Love, Dominic T.u Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)domlo927 |
| 700 | 1 | a Testini, Chiarau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi4 aut0 (Swepub:uu)chite685 |
| 700 | 1 | a Ninchoji, Takeshiu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)takni816 |
| 700 | 1 | a Smith, Ross O.u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi4 aut0 (Swepub:uu)rossm781 |
| 700 | 1 | a Ekvärn, Elisabetu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut |
| 700 | 1 | a Larsson, Jimmy,d 1977-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi,Molekylär systembiologi4 aut0 (Swepub:uu)jilar813 |
| 700 | 1 | a Roche, Francis P.u Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)fraro724 |
| 700 | 1 | a Egaña, Isabelu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut |
| 700 | 1 | a Jauhiainen, Suviu Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)suvja782 |
| 700 | 1 | a Berger, Philippu Paul Scherrer Inst, Lab Nanoscale Biol, Villigen, Switzerland.4 aut |
| 700 | 1 | a Claesson-Welsh, Lenau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi4 aut0 (Swepub:uu)lcl04207 |
| 700 | 1 | a Hellström, Matsu Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)mathe355 |
| 710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
| 773 | 0 | t EMBO Reportsd : EMBO Pressg 22:2q 22:2x 1469-221Xx 1469-3178 |
| 856 | 4 | u https://doi.org/10.15252/embr.202050218y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1543586/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.202050218 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-438815 |
| 856 | 4 8 | u https://doi.org/10.15252/embr.202050218 |
- 2 of 2
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nitzsche, Anja, ...
- Pietilä, Riikka
- Love, Dominic T.
- Testini, Chiara
- Ninchoji, Takesh ...
- Smith, Ross O.
- show more...
- Ekvärn, Elisabet
- Larsson, Jimmy, ...
- Roche, Francis P ...
- Egaña, Isabel
- Jauhiainen, Suvi
- Berger, Philipp
- Claesson-Welsh, ...
- Hellström, Mats
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- EMBO Reports
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
