Applicability of the European Society of Cardiology Guidelines on the management of acute coronary syndromes to older people with haemophilia A – A modified Delphi consensus by the ADVANCE Working Group

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Fältnamn	Indikatorer	Metadata
000		04365naa a2200565 4500
001		oai:lup.lub.lu.se:f67834f8-fa5d-4453-9fe3-469369d00c35
003		SwePub
008		230116s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/f67834f8-fa5d-4453-9fe3-469369d00c352 URI
024	7	a https://doi.org/10.1111/hae.146742 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Klamroth, Robertu Vivantes hospital im Friedrichshain4 aut
245	1 0	a Applicability of the European Society of Cardiology Guidelines on the management of acute coronary syndromes to older people with haemophilia A – A modified Delphi consensus by the ADVANCE Working Group
264		c 2022-10-21
264	1	b Wiley,c 2023
520		a Introduction: As people with haemophilia (PWH) receive better treatment and live longer they are more likely to encounter cardiovascular disease (CVD) and other comorbidities. ESC guidelines for the acute management of patients presenting with acute coronary syndrome (ACS) are based on the non-haemophilia population. Aim: To review the guidelines and propose relevant adaptations for PWHA without inhibitors who are treated with prophylaxis and present with ACS. Methods: As part of the ADVANCE Group, 20 European haemophilia experts used a modified Delphi approach to develop and gain consensus on proposed adaptations of the ESC guidelines for PWHA without inhibitors. Results: Of the 32 Class I recommendations across both guidelines, adaptions were considered necessary and proposed for 15. The adaptions highlight the need to provide sufficient FVIII trough levels at the time of antithrombotic treatment in people with haemophilia A (HA) without inhibitors. Patients receiving emicizumab prophylaxis and requiring oral anticoagulation therapy or combined single antiplatelet plus oral anticoagulation therapy will require additional FVIII replacement therapy. Conclusion: In the absence of high-quality clinical evidence, the combined expert opinion used to develop these adaptions to the current ESC guidelines may help to guide clinicians in their treatment decisions when a PWHA presents with ACS.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
653		a acute coronary syndrome
653		a consensus
653		a guidelines
653		a haemophilia
700	1	a Ay, Cihanu Medical University of Vienna4 aut
700	1	a De Moerloose, Philippeu University of Geneva Medical School4 aut
700	1	a Fontana, Pierreu Geneva University Hospital4 aut
700	1	a Windyga, Jerzyu Institute of Haematology and Transfusion Medicine, Warsaw4 aut
700	1	a Astermark, Janu Skåne University Hospital4 aut0 (Swepub:lu)medf-jas
700	1	a Berntorp, Eriku Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)medf-ebe
700	1	a Carvalho, Manuela4 aut
700	1	a Dolan, Gerardu St Thomas' Hospital4 aut
700	1	a Hermans, Cedricu Saint-Luc University Hospital4 aut
700	1	a Holme, Pål Andreu Oslo university hospital4 aut
700	1	a Kenet, Giliu Tel-Aviv University4 aut
700	1	a Mancuso, Maria Elisa4 aut
700	1	a Marquardt, Nataschau University Hospital Bonn4 aut
700	1	a Nunez, Ramirou University Hospital Virgen del Rocío4 aut
700	1	a Pabinger, Ingridu Medical University of Vienna4 aut
700	1	a Rodgers, Ryanu Glasgow Royal Infirmary4 aut
700	1	a Valk, Paul van deru University Medical Center Utrecht4 aut
700	1	a Yuste, Victor Jimenezu University Hospital La Paz4 aut
700	1	a Zupan, Irena Preložniku University Medical Centre Ljubljana4 aut
710	2	a Vivantes hospital im Friedrichshainb Medical University of Vienna4 org
773	0	t Haemophiliad : Wileyg 29:1, s. 21-32q 29:1<21-32x 1351-8216x 1365-2516
856	4	u http://dx.doi.org/10.1111/hae.14674y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/f67834f8-fa5d-4453-9fe3-469369d00c35
856	4 8	u https://doi.org/10.1111/hae.14674

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

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