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FältnamnIndikatorerMetadata
00005334naa a2200505 4500
001oai:DiVA.org:oru-113430
003SwePub
008240429s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1134302 URI
0247 a https://doi.org/10.1089/neu.2012.24862 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Toth, Arnoldu Department of Neurology, University of Pécs, Pécs, Hungary4 aut
2451 0a Multi-modal magnetic resonance imaging in the acute and sub-acute phase of mild traumatic brain injury :b can we see the difference?
264 1b Mary Ann Liebert,c 2013
338 a print2 rdacarrier
500 a This work was supported by Developing Competitiveness of Universities in the South Transdanubian Region (SROP-4.2.1.B-10/2/KONV-2010-0002).
520 a Advanced magnetic resonance imaging (MRI) methods were shown to be able to detect the subtle structural consequences of mild traumatic brain injury (mTBI). The objective of this study was to investigate the acute structural alterations and recovery after mTBI, using diffusion tensor imaging (DTI) to reveal axonal pathology, volumetric analysis, and susceptibility weighted imaging (SWI) to detect microhemorrhage. Fourteen patients with mTBI who had computed tomography with negative results underwent MRI within 3 days and 1 month after injury. High resolution T1-weighted imaging, DTI, and SWI, were performed at both time points. A control group of 14 matched volunteers were also examined following the same imaging protocol and time interval. Tract-Based Spatial Statistics (TBSS) were performed on DTI data to reveal group differences. T1-weighted images were fed into Freesurfer volumetric analysis. TBSS showed fractional anisotropy (FA) to be significantly (corrected p<0.05) lower, and mean diffusivity (MD) to be higher in the mTBI group in several white matter tracts (FA=40,737; MD=39,078 voxels) compared with controls at 72 hours after injury and still 1month later for FA. Longitudinal analysis revealed significant change (i.e., normalization) of FA and MD over 1 month dominantly in the left hemisphere (FA=3408; MD=7450 voxels). A significant (p<0.05) decrease in cortical volumes (mean 1%) and increase in ventricular volumes (mean 3.4%) appeared at 1 month after injury in the mTBI group. SWI did not reveal microhemorrhage in our patients. Our findings present dynamic micro- and macrostructural changes occurring in the acute to sub-acute phase in mTBI, in very mildly injured patients lacking microhemorrhage detectable by SWI. These results underscore the importance of strictly defined image acquisition time points when performing MRI studies on patients with mTBI. 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Adult brain injury
653 a axonal injury
653 a brain edema
653 a MRI
653 a recovery
7001 a Kovacs, Noemiu Department of Neurosurgery, University of Pécs, Pécs, Hungary4 aut
7001 a Perlaki, Gaboru Department of Neurology, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7001 a Orsi, Gergelyu Department of Neurology, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7001 a Aradi, Mihalyu Pécs Diagnostic Centre, Pécs, Hungary4 aut
7001 a Komaromy, Hedvigu Pécs Diagnostic Centre, Pécs, Hungary4 aut
7001 a Ezer, Erzsebetu Department of Neurosurgery, University of Pécs, Pécs, Hungary4 aut
7001 a Bukovics, Peteru Department of Neurosurgery, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7001 a Farkas, Orsolyau Department of Radiology, University of Pécs, Pécs, Hungary4 aut
7001 a Janszky, Jozsefu Department of Neurology, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7001 a Doczi, Tamasu Department of Neurosurgery, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7001 a Büki, Andras,d 1966-u Department of Neurosurgery, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut0 (Swepub:oru)asbi
7001 a Schwarcz, Attilau Department of Neurosurgery, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary4 aut
7102 a Department of Neurology, University of Pécs, Pécs, Hungaryb Department of Neurosurgery, University of Pécs, Pécs, Hungary4 org
7730 t Journal of Neurotraumad : Mary Ann Liebertg 30:1, s. 2-10q 30:1<2-10x 0897-7151x 1557-9042
8564 u http://real.mtak.hu/10175/1/T%C3%B3th%202013%20J%20Neurotrauma.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113430
8564 8u https://doi.org/10.1089/neu.2012.2486

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