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Sökning: WFRF:(Ortega Fatima) > (2017) > The multistate tube...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004608naa a2200469 4500
001oai:DiVA.org:uu-318691
003SwePub
008170328s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3186912 URI
0247 a https://doi.org/10.1007/s10928-017-9508-22 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chen, Chunliu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)chuch828
2451 0a The multistate tuberculosis pharmacometric model :b a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model
264 c 2017-02-15
264 1b Springer Science and Business Media LLC,c 2017
338 a electronic2 rdacarrier
520 a The Multistate Tuberculosis Pharmacometric (MTP) model, a pharmacokinetic-pharmacodynamic disease model, has been used to describe the effects of rifampicin on Mycobacterium tuberculosis (M. tuberculosis) in vitro. The aim of this work was to investigate if the MTP model could be used to describe the rifampicin treatment response in an acute tuberculosis mouse model. Sixty C57BL/6 mice were intratracheally infected with M. tuberculosis H37Rv strain on Day 0. Fifteen mice received no treatment and were sacrificed on Days 1, 9 and 18 (5 each day). Twenty-five mice received oral rifampicin (1, 3, 9, 26 or 98 mg·kg-1·day-1; Days 1–8; 5 each dose level) and were sacrificed on Day 9. Twenty mice received oral rifampicin (30 mg·kg-1·day-1; up to 8 days) and were sacrificed on Days 2, 3, 4 and 9 (5 each day). The MTP model was linked to a rifampicin population pharmacokinetic model to describe the change in colony forming units (CFU) in the lungs over time. The transfer rates between the different bacterial states were fixed to estimates from in vitro data. The MTP model described well the change in CFU over time after different exposure levels of rifampicin in an acute tuberculosis mouse model. Rifampicin significantly inhibited the growth of fast-multiplying bacteria and stimulated the death of fast- and slow-multiplying bacteria. The data did not support an effect of rifampicin on non-multiplying bacteria possibly due to the short duration of the study. The pharmacometric modelling framework using the MTP model can be used to perform investigations and predictions of the efficacy of anti-tubercular drugs against different bacterial states.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a Mouse
653 a Rifampicin
653 a Tuberculosis
653 a Pharmacokinetics
653 a Pharmacodynamics
7001 a Ortega, Fatimau Diseases of Developing World Medicines Development Campus, GlaxoSmithKline, Madrid, Spain4 aut
7001 a Rullas, Joaquinu Diseases of Developing World Medicines Development Campus, GlaxoSmithKline, Madrid, Spain4 aut
7001 a Alameda, Laurau Diseases of Developing World Medicines Development Campus, GlaxoSmithKline, Madrid, Spain4 aut
7001 a Angulo-Barturen, Iñigou Diseases of Developing World Medicines Development Campus, GlaxoSmithKline, Madrid, Spain.; Art Discovery TAD, Biscay Sci & Technol Pk,BIC Bizkaia Bldg,612, Bizkaia 48160, Basque Country, Spain4 aut
7001 a Ferrer, Santiagou Diseases of Developing World Medicines Development Campus, GlaxoSmithKline, Madrid, Spain4 aut
7001 a Svensson, Ulrika S Hu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)usv12211
7102 a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
7730 t Journal of Pharmacokinetics and Pharmacodynamicsd : Springer Science and Business Media LLCg 44:2, s. 133-141q 44:2<133-141x 1567-567Xx 1573-8744
8564 u https://doi.org/10.1007/s10928-017-9508-2y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1085399/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
8564 u https://uu.diva-portal.org/smash/get/diva2:1085399/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://link.springer.com/content/pdf/10.1007%2Fs10928-017-9508-2.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318691
8564 8u https://doi.org/10.1007/s10928-017-9508-2

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