Clinical Impact of Influenza Vaccination after ST- and Non-ST-segment elevation Myocardial Infarction Insights from the IAMI trial

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Clinical Impact of Influenza Vaccination after ST- and Non-ST-segment elevation Myocardial Infarction Insights from the IAMI trial

Fröbert, Ole, 1964- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Örebro, Sweden,Orebro Univ, Sweden; Orebro Univ, Sweden

Götberg, Matthias (author): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital

Erlinge, David (author): Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

Akhtar, Zubair (author): International Centre for Diarrhoeal Disease Research, Bangladesh, (icddr,b) Dhaka, Banglades,International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Dhaka, Bangladesh; The Kirby Institute, UNSW Medicine, University of New South Wales, NSW, Sydney, Australia,Int Ctr Diarrhoeal Dis Res, Bangladesh; Univ New South Wales, Australia

Christiansen, Evald H. (author): Department of Cardiology, Aarhus University Hospital, Aarhus, Aarhus, Denmark,Aarhus Univ Hosp, Denmark

MacIntyre, Chandini R. (author): The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia

Oldroyd, Keith G. (author): Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom and West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, Scotland, Glasgow, United Kingdom,Univ Glasgow, Scotland; Golden Jubilee Natl Hosp, Scotland

Motovska, Zuzana (author): Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic and University Hospital Kralovske Vinohrady, Bohemia, Prague, Czech Republic,Charles Univ Prague, Czech Republic; Univ Hosp Kralovske Vinohrady, Czech Republic

Erglis, Andrejs (author): Pauls Stradins Clinical University Hospital, University of Latvia, Riga, Riga, Latvia,Univ Latvia, Latvia

Moer, Rasmus (author): LHL-sykehuset Gardermoen, Ostiandet, Oslo, Norway

Hlinomaz, Ota (author): nternational clinical research center, St. Anne University Hospital and Masaryk University, South Moravian, Brno, Czech Republic,Masaryk Univ, Czech Republic

Jakobsen, Lars (author): Department of Cardiology, Aarhus University Hospital, Aarhus, Aarhus, Denmark,Aarhus Univ Hosp, Denmark

Engstrøm, Thomas (author): Rigshospitalet, University of Copenhagen, Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark,Copenhagen University Hospital

Jensen, Lisette O. (author): Department of Cardiology, Odense University Hospital, Odense, Odense, Denmark,Odense Univ Hosp, Denmark

Fallesen, Christian O. (author): Department of Cardiology, Odense University Hospital, Odense, Odense, Denmark,Odense Univ Hosp, Denmark

Jensen, Svend E. (author): Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aalborg University, Kommune, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Aalborg Univ, Denmark

Angerås, Oskar, 1976 (author): Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Calais, Fredrik, 1971- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Örebro, Sweden,Orebro Univ, Sweden

Kåregren, Amra (author): Västmanlands sjukhus Västerås, Västmanland, Västerås, Sweden,Västmanland Hospital

Lauermann, Jörg (author): Linköping University,Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Dept Cardiol, Jönköping, Region Jönköping County, Sweden

Mokhtari, Arash (author): Lund University,Lunds universitet,NPWT teknologin,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,NPWT technology,Lund University Research Groups,Less invasive cardiac surgery,Skåne University Hospital

Nilsson, Johan (author): Umeå University,Umeå universitet,Kardiologi,Umea Univ, Sweden

Persson, Jonas (author): Karolinska Institutet,Karolinska Institute,Danderyd Hospital

Stalby, Per (author): Department of Cardiology, Karlstad Central Hospital, Värmland, Karlstad, Sweden,Karlstad Cent Hosp, Sweden

Islam, Abu K. M. M. (author): National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Dhaka, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh

Rahman, Afzalur (author): National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Dhaka, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh

Malik, Fazila (author): National Heart Foundation Hospital & Research Institute, Dhaka, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh

Choudhury, Sohel (author): National Heart Foundation Hospital & Research Institute, Dhaka, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh

Collier, Timothy (author): Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, London, United Kingdom,London Sch Hyg & Trop Med, England

Pocock, Stuart J. (author): Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, London, United Kingdom,London Sch Hyg & Trop Med, England

Pernow, John (author): Karolinska Institutet,Karolinska Institute,Karolinska University Hospital

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Elsevier, 2023
2023
English.
In: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 255, s. 82-89

Related links:: https://oru.diva-por... (primary) (Raw object); show more...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; https://gup.ub.gu.se...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Influenza vaccination early after myocardial infarction (MI) improves prognosis but vaccine effectiveness may differ dependent on type of MI.METHODS: A total of 2571 participants were prospectively enrolled in the IAMI trial and randomly assigned to receive in-hospital inactivated influenza vaccine or saline placebo. The trial was conducted at 30 centers in 8 countries from October 1, 2016 to March 1, 2020. Here we report vaccine effectiveness in the 2467 participants with ST-segment elevation MI (STEMI, n=1348) or non-ST-segment elevation MI (NSTEMI, n=1119). The primary endpoint was the composite of all-cause death, MI, or stent thrombosis at 12 months. Cumulative incidence of the primary and key secondary endpoints by randomized treatment and NSTEMI/STEMI was estimated using the Kaplan-Meier method. Treatment effects were evaluated with formal interaction testing to assess for effect modification.RESULTS: Baseline risk was higher in participants with NSTEMI. In the NSTEMI group the primary endpoint occurred in 6.5% of participants assigned to influenza vaccine and 10.5% assigned to placebo (hazard ratio [HR], 0.60; 95% CI, 0.39-0.91), compared to 4.1% assigned to influenza vaccine and 4.5% assigned to placebo in the STEMI group (HR, 0.90; 95% CI, 0.54-1.50, P=0.237 for interaction). Similar findings were seen for the key secondary endpoints of all-cause death and cardiovascular death. The Kaplan-Meier risk difference in all-cause death at 1 year was more pronounced in participants with NSTEMI (NSTEMI: HR, 0.47; 95% CI 0.28-0.80, STEMI: HR, 0.86; 95% CI, 0.43-1.70, interaction P=0.028).CONCLUSIONS: The beneficial effect of influenza vaccination on adverse cardiovascular events may be enhanced in patients with NSTEMI compared to those with STEMI.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: American Heart J ...

By the university: Örebro University; Umeå University; Linköping University; Lund University; Karolinska Institutet; University of Gothenburg

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Clinical Impact of Influenza Vaccination after ST- and Non-ST-segment elevation Myocardial Infarction Insights from the IAMI trial

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