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Sökning: WFRF:(Ramsey Goldman Rosalind) > (2010-2014) > Cancer risk in syst...

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FältnamnIndikatorerMetadata
00005323naa a2200865 4500
001oai:lup.lub.lu.se:e4f61ce6-068f-4087-a6a7-a35d1c7a04df
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/39311652 URI
0247 a https://doi.org/10.1016/j.jaut.2012.12.0092 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bernatsky, Sasha4 aut
2451 0a Cancer risk in systemic lupus: An updated international multi-centre cohort study
264 1b Elsevier BV,c 2013
520 a Objective: To update estimates of cancer risk in SLE relative to the general population. Methods: A multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Results: Across 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% Cl 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23). Conclusion: These data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing. (C) 2013 Elsevier Ltd. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Systemic lupus erythematosus
653 a Epidemiology
653 a Treatment
653 a Disease activity
7001 a Ramsey-Goldman, Rosalind4 aut
7001 a Labrecque, Jeremy4 aut
7001 a Joseph, Lawrence4 aut
7001 a Boivin, Jean-Francois4 aut
7001 a Petri, Michelle4 aut
7001 a Zoma, Asad4 aut
7001 a Manzi, Susan4 aut
7001 a Urowitz, Murray B.4 aut
7001 a Gladman, Dafna4 aut
7001 a Fortin, Paul R.4 aut
7001 a Ginzler, Ellen4 aut
7001 a Yelin, Edward4 aut
7001 a Bae, Sang-Cheol4 aut
7001 a Wallace, Daniel J.4 aut
7001 a Edworthy, Steven4 aut
7001 a Jacobsen, Soren4 aut
7001 a Gordon, Caroline4 aut
7001 a Dooley, Mary Anne4 aut
7001 a Peschken, Christine A.4 aut
7001 a Hanly, John G.4 aut
7001 a Alarcon, Graciela S.4 aut
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
7001 a Ruiz-Irastorza, Guillermo4 aut
7001 a Isenberg, David4 aut
7001 a Rahman, Anisur4 aut
7001 a Witte, Torsten4 aut
7001 a Aranow, Cynthia4 aut
7001 a Kamen, Diane L.4 aut
7001 a Steinsson, Kristjan4 aut
7001 a Askanase, Anca4 aut
7001 a Barr, Susan4 aut
7001 a Criswell, Lindsey A.4 aut
7001 a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst
7001 a Patel, Neha M.4 aut
7001 a Senecal, Jean-Luc4 aut
7001 a Zummer, Michel4 aut
7001 a Pope, Janet E.4 aut
7001 a Ensworth, Stephanie4 aut
7001 a El-Gabalawy, Hani4 aut
7001 a McCarthy, Timothy4 aut
7001 a Dreyer, Lene4 aut
7001 a Sibley, John4 aut
7001 a St Pierre, Ivan4 aut
7001 a Clarke, Ann E.4 aut
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t Journal of Autoimmunityd : Elsevier BVg 42, s. 130-135q 42<130-135x 0896-8411
8564 u http://dx.doi.org/10.1016/j.jaut.2012.12.009y FULLTEXT
8564 u https://europepmc.org/articles/pmc3646904?pdf=render
8564 8u https://lup.lub.lu.se/record/3931165
8564 8u https://doi.org/10.1016/j.jaut.2012.12.009

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