Aerobic capacity over 16 years in patients with rheumatoid arthritis: relationship to disease activity and risk factors for cardiovascular disease

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Fältnamn	Indikatorer	Metadata
000		03795naa a2200361 4500
001		oai:DiVA.org:umu-143932
003		SwePub
008		180116s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1439322 URI
024	7	a https://doi.org/10.1371/journal.pone.01902112 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hörnberg, Kristinau Umeå universitet,Reumatologi4 aut0 (Swepub:umu)krahog83
245	1 0	a Aerobic capacity over 16 years in patients with rheumatoid arthritis :b relationship to disease activity and risk factors for cardiovascular disease
264		c 2017-12-22
264	1	b Public library science,c 2017
338		a electronic2 rdacarrier
520		a The aim of this study was to analyse the change in aerobic capacity from disease onset of rheumatoid arthritis (RA) over 16.2 years, and its associations with disease activity and cardiovascular risk factors. Twenty-five patients (20 f/5 m), diagnosed with RA 1995-2002 were tested at disease onset and after mean 16.2 years. Parameters measured were: sub-maximal ergometer test for aerobic capacity, functional ability, self-efficacy, ESR, CRP and DAS28. At follow-up, cardiovascular risk factors were assessed as blood lipids, glucose concentrations, waist circumference, body mass index (BMI), body composition, pulse wave analysis and carotid intima-media thickness. Aerobic capacity [median (IQR)] was 32.3 (27.9-42.1) ml O2/kg x min at disease onset, and 33.2 (28.4-38.9) at follow-up (p>0.05). Baseline aerobic capacity was associated with follow-up values of: BMI (rs = -.401, p = .047), waist circumference (rs = -.498, p = .011), peripheral pulse pressure (rs = -.415, p = .039) self-efficacy (rs = .420, p = .037) and aerobic capacity (rs = .557, p = .004). In multiple regression models adjusted for baseline aerobic capacity, disease activity at baseline and over time predicted aerobic capacity at follow-up (AUC DAS28, 0-24 months; β = -.14, p = .004). At follow-up, aerobic capacity was inversely associated with blood glucose levels (rs = -.508, p = .016), BMI (rs = -.434, p = .030), body fat% (rs = -.419, p = .037), aortic pulse pressure (rs = -.405, p = .044), resting heart rate (rs = -.424, p = .034) and self-efficacy (rs = .464, p = .020) at follow-up. We conclude that the aerobic capacity was maintained over 16 years. High baseline aerobic capacity associated with favourable measures of cardiovascular risk factors at follow-up. Higher disease activity in early stages of RA predicted lower aerobic capacity after 16.2 years.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Sundström, Björnu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)bjnsum99
700	1	a Innala, Lenau Umeå universitet,Reumatologi4 aut0 (Swepub:umu)lein0016
700	1	a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
700	1	a Wållberg-Jonsson, Solveigu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
710	2	a Umeå universitetb Reumatologi4 org
773	0	t PLOS ONEd : Public library scienceg 12:12q 12:12x 1932-6203
856	4	u https://umu.diva-portal.org/smash/get/diva2:1174547/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0190211&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143932
856	4 8	u https://doi.org/10.1371/journal.pone.0190211

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