WFRF:(Resnick S. M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04554naa a2200733 4500 | |
| 001 | oai:gup.ub.gu.se/285996 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2859962 URI |
| 024 | 7 | a https://doi.org/10.1093/brain/awz2062 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dumitrescu, L.4 aut |
| 245 | 1 0 | a Sex differences in the genetic predictors of Alzheimer's pathology |
| 264 | c 2019-07-20 | |
| 264 | 1 | b Oxford University Press (OUP),c 2019 |
| 520 | a Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer's disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer's disease endophenotypes from six brain bank data repositories. The pooled dataset included 2701 males and 3275 females, the majority of whom were diagnosed with Alzheimer's disease at autopsy (70%). Sex-stratified GWAS were performed within each dataset and then meta-analysed. Loci that reached genome-wide significance (P < 5 x 10(-8)) in stratified models were further assessed for sex interactions. Additional analyses were performed in independent datasets leveraging cognitive, neuroimaging and CSF endophenotypes, along with age-at-onset data. Outside of the APOE region, one locus on chromosome 7 (rs34331204) showed a sex-specific association with neurofibrillary tangles among males (P = 2.5 x 10(-8)) but not females (P = 0.85, sex-interaction P = 2.9 x 10(-4)). In follow-up analyses, rs34331204 was also associated with hippocampal volume, executive function, and age-at-onset only among males. These results implicate a novel locus that confers male-specific protection from tau pathology and highlight the value of assessing genetic associations in a sex-specific manner. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Barnes, L. L.4 aut |
| 700 | 1 | a Thambisetty, M.4 aut |
| 700 | 1 | a Beecham, G.4 aut |
| 700 | 1 | a Kunkle, B.4 aut |
| 700 | 1 | a Bush, W. S.4 aut |
| 700 | 1 | a Gifford, K. A.4 aut |
| 700 | 1 | a Chibnik, L. B.4 aut |
| 700 | 1 | a Mukherjee, S.4 aut |
| 700 | 1 | a De Jager, P. L.4 aut |
| 700 | 1 | a Kukull, W.4 aut |
| 700 | 1 | a Crane, P. K.4 aut |
| 700 | 1 | a Resnick, S. M.4 aut |
| 700 | 1 | a Keene, C. D.4 aut |
| 700 | 1 | a Montine, T. J.4 aut |
| 700 | 1 | a Schellenberg, G. D.4 aut |
| 700 | 1 | a Deming, Y.4 aut |
| 700 | 1 | a Chao, M. J.4 aut |
| 700 | 1 | a Huentelman, M.4 aut |
| 700 | 1 | a Martin, E. R.4 aut |
| 700 | 1 | a Hamilton-Nelson, K.4 aut |
| 700 | 1 | a Shaw, L. M.4 aut |
| 700 | 1 | a Trojanowski, J. Q.4 aut |
| 700 | 1 | a Peskind, E. R.4 aut |
| 700 | 1 | a Cruchaga, C.4 aut |
| 700 | 1 | a Pericak-Vance, M. A.4 aut |
| 700 | 1 | a Goate, A. M.4 aut |
| 700 | 1 | a Cox, N. J.4 aut |
| 700 | 1 | a Haines, J. L.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Larson, E. B.4 aut |
| 700 | 1 | a Johnson, S. C.4 aut |
| 700 | 1 | a Albert, M.4 aut |
| 700 | 1 | a Bennett, D. A.4 aut |
| 700 | 1 | a Schneider, J. A.4 aut |
| 700 | 1 | a Jefferson, A. L.4 aut |
| 700 | 1 | a Hohman, T. J.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Braind : Oxford University Press (OUP)g 142, s. 2581-2589q 142<2581-2589x 0006-8950x 1460-2156 |
| 856 | 4 | u https://academic.oup.com/brain/article-pdf/142/9/2581/29222518/awz206.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/285996 |
| 856 | 4 8 | u https://doi.org/10.1093/brain/awz206 |
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- Barnes, L. L.
- Thambisetty, M.
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- Bush, W. S.
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- Gifford, K. A.
- Chibnik, L. B.
- Mukherjee, S.
- De Jager, P. L.
- Kukull, W.
- Crane, P. K.
- Resnick, S. M.
- Keene, C. D.
- Montine, T. J.
- Schellenberg, G. ...
- Deming, Y.
- Chao, M. J.
- Huentelman, M.
- Martin, E. R.
- Hamilton-Nelson, ...
- Shaw, L. M.
- Trojanowski, J. ...
- Peskind, E. R.
- Cruchaga, C.
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- Goate, A. M.
- Cox, N. J.
- Haines, J. L.
- Zetterberg, Henr ...
- Blennow, Kaj, 19 ...
- Larson, E. B.
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- Bennett, D. A.
- Schneider, J. A.
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- Hohman, T. J.
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