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- Eriksson, Bengt I.,1946Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics (författare)
Concomitant use of medication with antiplatelet effects in patients receiving either rivaroxaban or enoxaparin after total hip or knee arthroplasty.
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- Elsevier BV,2012
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/156761
- https://gup.ub.gu.se/publication/156761URI
- https://doi.org/10.1016/j.thromres.2011.12.005DOI
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- Språk:engelska
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- SwePubSwePub
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- INTRODUCTION: The RECORD programme compared oral rivaroxaban with enoxaparin for prevention of venous thromboembolism after elective total hip or knee replacement. This analysis compared the safety of concomitant use of specified medications with rivaroxaban and enoxaparin by evaluating postoperative bleeding rates from the pooled RECORD1-4 data. MATERIALS AND METHODS: The co-medications were non-steroidal anti-inflammatory drugs and platelet function inhibitors, including acetylsalicylic acid (no dose restriction). The endpoints evaluated were the composite of major and non-major clinically relevant bleeding and any bleeding occurring after first oral study drug intake. The time relative to surgery was stratified into three time periods: day 1-3, day 4-7 and after day 7. Relative bleeding rate ratios for co-medication use versus non-use were derived using stratified Mantel-Haenszel methods and compared between rivaroxaban and enoxaparin groups. RESULTS: Co-medication use with rivaroxaban or enoxaparin resulted in non-significant increases in bleeding events. Respective rate ratios were not significantly different between rivaroxaban and enoxaparin for all bleeding endpoints with concomitant use of non-steroidal anti-inflammatory drugs (any bleeding, 1.22 vs 1.22; major and non-major clinically relevant bleeding, 1.28 vs 0.90) and with concomitant use of platelet function inhibitors/acetylsalicylic acid (any bleeding, 1.32 vs 1.40; major and non-major clinically relevant bleeding, 1.11 vs 1.13). CONCLUSIONS: This explorative analysis indicates that there is no significant increase in bleeding risk for rivaroxaban compared with enoxaparin when co-administered with non-steroidal anti-inflammatory drugs or acetylsalicylic acid, although, because of low usage, the experience with platelet function inhibitors (except acetylsalicylic acid) was limited.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- Drug interactions; Non-steroidal anti-inflammatory agents; Platelet function inhibitors; Rivaroxaban; Total hip arthroplasty; Total knee arthroplasty
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Rosencher, Nadia (författare)
- Friedman, Richard J (författare)
- Homering, Martin (författare)
- Dahl, Ola E (författare)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för ortopedi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Thrombosis research: Elsevier BV130:2, s. 147-1511879-24720049-3848
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- Eriksson, Bengt ...
- Rosencher, Nadia
- Friedman, Richar ...
- Homering, Martin
- Dahl, Ola E
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kirurgi
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- Thrombosis resea ...
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- Göteborgs universitet
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