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- Imamura, TeruhikoUniversity of Tokyo, Japan (author)
A case with recovery of response to tolvaptan associated with remission of acute kidney injury and increased urine osmolality
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- International Heart Journal Association,2013
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-111186
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111186URI
- https://doi.org/10.1536/ihj.54.115DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
Classification
Notes
- Tolvaptan (TLV), a vasopressin type 2 receptor antagonist, has been demonstrated to be effective in patients with decompensated heart failure (HF) refractory to incremental doses of diuretics, but the responsiveness has not always been predictable. We have recently proposed that urine osmolality (U-OSM) is a valuable parameter for the prediction of responses to TLV, because U-OSM reflects the activity of the collecting ducts, where TLV plays its unique role. Acute kidney injury (AKI) is often associated with severe tubular dysfunction, including the collecting ducts, and in such cases a response to TLV may not be expected. We here experienced a patient with HF and AKI in whom TLV was not effective during AKI. We also observed recovery of responsiveness to TLV along with remission of AKI as well as increased U-OSM later on. We believe that this is the first report on the reversibility of the TLV response in relation to U-OSM.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng
- Renal dysfunction; Vasopressin; Heart failure; Rejection
Added entries (persons, corporate bodies, meetings, titles ...)
- Kinugawa, KoichiroUniversity of Tokyo, Japan (author)
- Kato, NaokoUniversity of Tokyo, Japan(Swepub:liu)naope77 (author)
- Minatsuki, ShunUniversity of Tokyo, Japan (author)
- Muraoka, HironoriUniversity of Tokyo, Japan (author)
- Inaba, ToshiroUniversity of Tokyo, Japan (author)
- Maki, HisatakaUniversity of Tokyo, Japan (author)
- Shiga, TaroUniversity of Tokyo, Japan (author)
- Hatano, MasaruUniversity of Tokyo, Japan (author)
- Hosoya, YumikoUniversity of Tokyo, Japan (author)
- Takahashi, MasaoUniversity of Tokyo, Japan (author)
- Yao, AtsushiUniversity of Tokyo, Japan (author)
- Kyo, ShuneiUniversity of Tokyo, Japan (author)
- Ono, MinoruUniversity of Tokyo, Japan (author)
- Komuro, IsseiUniversity of Tokyo, Japan (author)
- University of Tokyo, Japan (creator_code:org_t)
Related titles
- In:International Heart Journal: International Heart Journal Association54:2, s. 115-1181349-23651349-3299
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