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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003230naa a2200469 4500
001oai:DiVA.org:liu-111186
003SwePub
008141010s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1111862 URI
0247 a https://doi.org/10.1536/ihj.54.1152 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Imamura, Teruhikou University of Tokyo, Japan4 aut
2451 0a A case with recovery of response to tolvaptan associated with remission of acute kidney injury and increased urine osmolality
264 1b International Heart Journal Association,c 2013
338 a print2 rdacarrier
520 a Tolvaptan (TLV), a vasopressin type 2 receptor antagonist, has been demonstrated to be effective in patients with decompensated heart failure (HF) refractory to incremental doses of diuretics, but the responsiveness has not always been predictable. We have recently proposed that urine osmolality (U-OSM) is a valuable parameter for the prediction of responses to TLV, because U-OSM reflects the activity of the collecting ducts, where TLV plays its unique role. Acute kidney injury (AKI) is often associated with severe tubular dysfunction, including the collecting ducts, and in such cases a response to TLV may not be expected. We here experienced a patient with HF and AKI in whom TLV was not effective during AKI. We also observed recovery of responsiveness to TLV along with remission of AKI as well as increased U-OSM later on. We believe that this is the first report on the reversibility of the TLV response in relation to U-OSM.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
653 a Renal dysfunction; Vasopressin; Heart failure; Rejection
7001 a Kinugawa, Koichirou University of Tokyo, Japan4 aut
7001 a Kato, Naokou University of Tokyo, Japan4 aut0 (Swepub:liu)naope77
7001 a Minatsuki, Shunu University of Tokyo, Japan4 aut
7001 a Muraoka, Hironoriu University of Tokyo, Japan4 aut
7001 a Inaba, Toshirou University of Tokyo, Japan4 aut
7001 a Maki, Hisatakau University of Tokyo, Japan4 aut
7001 a Shiga, Tarou University of Tokyo, Japan4 aut
7001 a Hatano, Masaruu University of Tokyo, Japan4 aut
7001 a Hosoya, Yumikou University of Tokyo, Japan4 aut
7001 a Takahashi, Masaou University of Tokyo, Japan4 aut
7001 a Yao, Atsushiu University of Tokyo, Japan4 aut
7001 a Kyo, Shuneiu University of Tokyo, Japan4 aut
7001 a Ono, Minoruu University of Tokyo, Japan4 aut
7001 a Komuro, Isseiu University of Tokyo, Japan4 aut
7102 a University of Tokyo, Japan4 org
7730 t International Heart Journald : International Heart Journal Associationg 54:2, s. 115-118q 54:2<115-118x 1349-2365x 1349-3299
8564 u https://www.jstage.jst.go.jp/article/ihj/54/2/54_115/_pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111186
8564 8u https://doi.org/10.1536/ihj.54.115

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