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A novel polypeptide...
A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the rat.
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Nilsson, Elin, 1983 (author)
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Björn, Camilla (author)
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Sjöstrand, Veronika (author)
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show more...
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Lindgren, Kerstin (author)
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Münnich, Mattias (author)
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- Mattsby-Baltzer, Inger, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Ivarsson, Marie-Louise, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Olmarker, Kjell, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics
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Mahlapuu, Margit, 1972 (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Annals of surgery. - 1528-1140. ; 250:6, s. 1021-8
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- OBJECTIVE: The objective of the study was to evaluate whether a peptide derived from human lactoferrin, PXL01 could act safely to reduce the formation of peritoneal adhesions in the rat model and to map the molecular mechanisms of its action. SUMMARY BACKGROUND DATA: Adhesion formation is a significant problem within every surgical discipline causing suffering for the patients and major cost for the society. For many decades, attempts have been made to reduce postsurgical adhesions by reducing surgical trauma. It is now believed that major improvements in adhesion prevention will only be reached by developing dedicated antiscarring products, which are administrated in connection to the surgical intervention. METHODS: Anti-inflammatory as well as fibrinolytic activities of PXL01 were studied in relevant human cell lines. Using the sidewall defect-cecum abrasion model in the rat, the adhesion prevention properties of PXL01 formulated in sodium hyaluronate were evaluated. Large bowel anastomosis healing model in the rat was applied to study if PXL01 would have any negative effects on intestine healing. Results: PXL01 exhibits an inhibitory effect on the most important hallmarks of scar formation by reducing infections, prohibiting inflammation, and promoting fibrinolysis. PXL01 formulated in sodium hyaluronate markedly reduced formation of peritoneal adhesions in rat without any adverse effects on wound healing. CONCLUSIONS: A new class of synthetically derived water soluble low molecular weight peptide compound, PXL01 showed marked reduction of peritoneal adhesion formation in an animal model without any negative effects on healing. On the basis of these data, a comprehensive adhesion prevention regimen in clinical situation is expected.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adjuvants
- Immunologic
- pharmacology
- Animals
- Carrier Proteins
- pharmacology
- Cells
- Cultured
- Disease Models
- Animal
- Drug Compounding
- Female
- Humans
- Hyaluronic Acid
- pharmacology
- Peritoneal Diseases
- metabolism
- pathology
- prevention & control
- Postoperative Complications
- Rats
- Rats
- Sprague-Dawley
- Tissue Adhesions
- prevention & control
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nilsson, Elin, 1 ...
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Björn, Camilla
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Sjöstrand, Veron ...
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Lindgren, Kersti ...
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Münnich, Mattias
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Mattsby-Baltzer, ...
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show more...
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Ivarsson, Marie- ...
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Olmarker, Kjell, ...
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Mahlapuu, Margit ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Annals of surger ...
- By the university
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University of Gothenburg