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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004144naa a2200541 4500
001oai:DiVA.org:uu-258971
003SwePub
008150723s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123662822
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2589712 URI
0247 a https://doi.org/10.1002/art.306242 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1236628222 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sreih, Antoine4 aut
2451 0a Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus
264 c 2011-11-29
264 1b Wiley,c 2011
338 a print2 rdacarrier
520 a Objective To study the effect of the innate cytokine macrophage migration inhibitory factor (MIF) on the susceptibility and severity of systemic lupus erythematosus (SLE) in a multinational population of 1,369 Caucasian and African American patients. Methods. Two functional polymorphisms in the MIF gene, a -794 CATT5-8 microsatellite repeat (rs5844572) and a -173 G/C single-nucleotide polymorphism (rs755622), were assessed for association with SLE in 3,195 patients and healthy controls. We also measured MIF plasma levels in relation to genotypes and clinical phenotypes, and assessed Toll-like receptor 7 (TLR-7)-stimulated MIF production in vitro. Results. Both Caucasians and African Americans with the high-expression MIF haplotype -794 CATT(7)/ -173* C had a lower incidence of SLE (in Caucasians, odds ratio [OR] 0.63, 95% confidence interval [95% CI] 0.53-0.89, P = 0.001; in African Americans, OR 0.46, 95% CI 0.23-0.95, P = 0.012). In contrast, among patients with established SLE, reduced frequencies of low-expression MIF genotypes (-794 CATT(5)) were observed in those with nephritis, those with serositis, and those with central nervous system (CNS) involvement when compared to patients without end-organ involvement (P = 0.023, P = 0.005, and P = 0.04, respectively). Plasma MIF levels and TLR-7-stimulated MIF production in vitro reflected the underlying MIF genotype of the studied groups. Conclusion. These findings suggest that MIF, which has both proinflammatory properties and macrophage and B cell survival functions, exerts a dual influence on the immunopathogenesis of SLE. Highexpression MIF genotypes are associated with a reduced susceptibility to SLE and may contribute to an enhanced clearance of infectious pathogens. Once SLE develops, however, low-expression MIF genotypes may protect from ensuing inflammatory end-organ damage.
7001 a Ezzeddine, Rana4 aut
7001 a Leng, Lin4 aut
7001 a LaChance, Avery4 aut
7001 a Yu, Geraldine4 aut
7001 a Mizue, Yuka4 aut
7001 a Subrahmanyan, Lakshman4 aut
7001 a Pons-Estel, Bernardo A.4 aut
7001 a Abelson, Anna-Karinu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut
7001 a Gunnarsson, Ivau Karolinska Institutet4 aut
7001 a Svenungsson, Elisabetu Karolinska Institutet4 aut
7001 a Cavett, Joshua4 aut
7001 a Glenn, Stuart4 aut
7001 a Zhang, Lin4 aut
7001 a Montgomery, Ruth4 aut
7001 a Perl, Andras4 aut
7001 a Salmon, Jane4 aut
7001 a Alarcon-Riquelme, Marta E.u Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)martaala
7001 a Harley, John B.4 aut
7001 a Bucala, Richard4 aut
7102 a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org
7730 t Arthritis and Rheumatismd : Wileyg 63:12, s. 3942-3951q 63:12<3942-3951x 0004-3591x 1529-0131
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.30624
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258971
8564 8u https://doi.org/10.1002/art.30624
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123662822

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