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Towards robust gluc...
Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time
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- Seidemo, Anina (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Lehmann, Patrick M. (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Rydhög, Anna (författare)
- Skåne University Hospital
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- Wirestam, Ronnie (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Helms, Gunther (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Zhang, Yi (författare)
- Zhejiang University
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- Yadav, Nirbhay N. (författare)
- Johns Hopkins University School of Medicine
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- Sundgren, Pia C. (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Faculty of Medicine,Neuroradiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- van Zijl, Peter C. M. (författare)
- Johns Hopkins University School of Medicine
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- Knutsson, Linda (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Johns Hopkins University School of Medicine
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(creator_code:org_t)
- 2021-09-29
- 2022
- Engelska.
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Ingår i: NMR in Biomedicine. - : Wiley. - 0952-3480 .- 1099-1492. ; 35:2, s. 4624-4624
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Abstract
Ämnesord
Stäng
- Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1 and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning protocols, as a step towards making the glucose chemical exchange saturation transfer (glucoCEST) protocol more robust. Two different infusion durations (1.5 and 4.0 min) and saturation frequency offsets (1.2 and 2.0 ppm) were used. The effect of subject motion on the DGE signal was studied by using motion estimates retrieved from standard retrospective motion correction to create pseudo-DGE maps, where the apparent DGE signal changes were entirely caused by motion. Furthermore, the DGE AIFs were compared with venous blood glucose levels. A significant difference (p = 0.03) between arterial baseline and postinfusion DGE signal was found after D-glucose infusion. The results indicate that the measured DGE AIF signal change depends on both motion and blood glucose concentration change, emphasizing the need for sufficient motion correction in glucoCEST imaging. Finally, we conclude that a longer infusion duration (e.g. 3–4 min) should preferably be used in glucoCEST experiments, because it can minimize the glucose infusion side effects without negatively affecting the DGE signal change.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- AIF
- CEST
- DGE
- D-glucose
- glucoCEST
- motion correction
- perfusion
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Till lärosätets databas
- Av författaren/redakt...
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Seidemo, Anina
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Lehmann, Patrick ...
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Rydhög, Anna
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Wirestam, Ronnie
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Helms, Gunther
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Zhang, Yi
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visa fler...
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Yadav, Nirbhay N ...
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Sundgren, Pia C.
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van Zijl, Peter ...
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Knutsson, Linda
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Annan fysik
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NMR in Biomedici ...
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Lunds universitet