WFRF:(Thomas Sushma)
Sökning: WFRF:(Thomas Sushma) > (2019) > The absence of the ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02833naa a2200385 4500 | |
| 001 | oai:DiVA.org:umu-156351 | |
| 003 | SwePub | |
| 008 | 190212s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1563512 URI |
| 024 | 7 | a https://doi.org/10.1093/nar/gkz0482 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Garbacz, Marta A.4 aut |
| 245 | 1 0 | a The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity |
| 264 | c 2019-01-30 | |
| 264 | 1 | b Oxford University Press,c 2019 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The four B-family DNA polymerases α, δ, ϵ and ζ cooperate to accurately replicate the eukaryotic nuclear genome. Here, we report that a Saccharomyces cerevisiae strain encoding the pol2-16 mutation that lacks Pol ϵ's polymerase and exonuclease activities has increased dNTP concentrations and an increased mutation rate at the CAN1 locus compared to wild type yeast. About half of this mutagenesis disappears upon deleting the REV3 gene encoding the catalytic subunit of Pol ζ. The remaining, still strong, mutator phenotype is synergistically elevated in an msh6Δ strain and has a mutation spectrum characteristic of mistakes made by Pol δ. The results support a model wherein slow-moving replication forks caused by the lack of Pol ϵ's catalytic domains result in greater involvement of mutagenic DNA synthesis by Pol ζ as well as diminished proofreading by Pol δ during replication. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Cox, Phillip B.4 aut |
| 700 | 1 | a Sharma, Sushmau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)sush0003 |
| 700 | 1 | a Lujan, Scott A.4 aut |
| 700 | 1 | a Chabes, Andrei,c Professoru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)anch0002 |
| 700 | 1 | a Kunkel, Thomas A.4 aut |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t Nucleic Acids Researchd : Oxford University Pressg 47:8, s. 3986-3995q 47:8<3986-3995x 0305-1048x 1362-4962 |
| 856 | 4 | u https://doi.org/10.1093/nar/gkz048y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1287880/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://doi.org/10.1093/nar/gkz048 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156351 |
| 856 | 4 8 | u https://doi.org/10.1093/nar/gkz048 |
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