Sökning: WFRF:(Tibshirani Robert) > Gene expression pro...
Fältnamn | Indikatorer | Metadata |
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000 | 04067naa a2200529 4500 | |
001 | oai:DiVA.org:liu-28162 | |
003 | SwePub | |
008 | 091008s2004 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1950136 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-281622 URI |
024 | 7 | a https://doi.org/10.1073/pnas.03041461012 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19501362 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lapointe, Jacques4 aut |
245 | 1 0 | a Gene expression profiling identifies clinically relevant subtypes of prostate cancer |
264 | c 2004-01-07 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2004 |
338 | a print2 rdacarrier | |
520 | a Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation underlying this clinical heterogeneity, we profiled gene expression in 62 primary prostate tumors, as well as 41 normal prostate specimens and nine lymph node metastases, using cDNA microarrays containing ≈26,000 genes. Unsupervised hierarchical clustering readily distinguished tumors from normal samples, and further identified three subclasses of prostate tumors based on distinct patterns of gene expression. High-grade and advanced stage tumors, as well as tumors associated with recurrence, were disproportionately represented among two of the three subtypes, one of which also included most lymph node metastases. To further characterize the clinical relevance of tumor subtypes, we evaluated as surrogate markers two genes differentially expressed among tumor subgroups by using immunohistochemistry on tissue microarrays representing an independent set of 225 prostate tumors. Positive staining for MUC1, a gene highly expressed in the subgroups with "aggressive" clinicopathological features, was associated with an elevated risk of recurrence (P = 0.003), whereas strong staining for AZGP1, a gene highly expressed in the other subgroup, was associated with a decreased risk of recurrence (P = 0.0008). In multivariate analysis, MUC1 and AZGP1 staining were strong predictors of tumor recurrence independent of tumor grade, stage, and preoperative prostate-specific antigen levels. Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Li, Chundeu Karolinska Institutet4 aut |
700 | 1 | a Higgins, John P4 aut |
700 | 1 | a van de Rijn, Matt4 aut |
700 | 1 | a Bair, Eric4 aut |
700 | 1 | a Montgomery, Kelli4 aut |
700 | 1 | a Ferrari, Michelle4 aut |
700 | 1 | a Egevad, Larsu Karolinska Institutet4 aut |
700 | 1 | a Rayford, Walter4 aut |
700 | 1 | a Bergerheim, Ulf,d 1953-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ulfbe91 |
700 | 1 | a Ekman, Peter4 aut |
700 | 1 | a DeMarzo, Angelo M4 aut |
700 | 1 | a Tibshirani, Robert4 aut |
700 | 1 | a Botstein, David4 aut |
700 | 1 | a Brown, Patrick O4 aut |
700 | 1 | a Brooks, James D4 aut |
700 | 1 | a Pollack, Jonathan R4 aut |
710 | 2 | a Karolinska Institutetb Hälsouniversitetet4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 101:3, s. 811-816q 101:3<811-816x 0027-8424x 1091-6490 |
856 | 4 | u https://europepmc.org/articles/pmc321763?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-28162 |
856 | 4 8 | u https://doi.org/10.1073/pnas.0304146101 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1950136 |
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