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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003669naa a2200361 4500
001oai:DiVA.org:ri-6745
003SwePub
008160908s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-67452 URI
0247 a https://doi.org/10.1016/j.ijheh.2013.12.0012 DOI
040 a (SwePub)ri
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Callesen, Michael Thudeu Odense University Hospital, Denmark4 aut
2451 0a Phthalate metabolites in urine and asthma, allergic rhinoconjunctivitis and atopic dermatitis in preschool children
264 1b Elsevier BV,c 2014
338 a print2 rdacarrier
520 a Phthalate esters are among the most ubiquitous of indoor pollutants and have been associated with various adverse health effects. In the present study we assessed the cross-sectional association between eight different phthalate metabolites in urine and allergic disease in young children. As part of the Danish Indoor Environment and Children's Health study, urine samples were collected from 440 children aged 3-5 years, of whom 222 were healthy controls, 68 were clinically diagnosed with asthma, 76 with rhinoconjunctivitis and 81 with atopic dermatitis (disease subgroups are not mutually exclusive; some children had more than one disease). There were no statistically significant differences in the urine concentrations of phthalate metabolites between cases and healthy controls with the exception of MnBP and MECPP, which were higher in healthy controls compared with the asthma case group. In the crude analysis MnBP and MiBP were negatively associated with asthma. In the analysis adjusted for multiple factors, only a weak positive association between MEP in urine and atopic dermatitis was found; there were no positive associations between any phthalate metabolites in urine and either asthma or rhinoconjunctivitis. These findings appear to contradict earlier studies. Differences may be due to higher exposures to certain phthalates (e.g., BBzP) via non-dietary pathways in earlier studies, phthalates serving as surrogates for an agent associated with asthma (e.g., PVC flooring) in previous studies but not the present study or altered cleaning habits and the use of "allergy friendly" products by parents of children with allergic disease in the current study in contrast to studies conducted earlier.
7001 a Bekö, Gabrielu DTU Technical University of Denmark, Denmark4 aut
7001 a Weschler, Charles J.u DTU Technical University of Denmark, Denmark; Rutgers University, USA4 aut
7001 a Langer, Sarkau IVL Swedish Environmental Research Institute, Sweden4 aut
7001 a Brive, Lenau RISE,SP – Sveriges Tekniska Forskningsinstitut / Organisk kemi (Kmo)4 aut
7001 a Clausen, Geou DTU Technical University of Denmark, Denmark4 aut
7001 a Toftum, J.u DTU Technical University of Denmark, Denmark4 aut
7001 a Sigsgaard, Torbenu University of Aarhus, Denmark4 aut
7001 a Høst, Arne H.u Odense University Hospital, Denmark4 aut
7001 a Jensen, Tina Koldu University of Southern Denmark, Denmark4 aut
7102 a Odense University Hospital, Denmarkb DTU Technical University of Denmark, Denmark4 org
7730 t International journal of hygiene and environmental healthd : Elsevier BVg 217:6, s. 645-652q 217:6<645-652x 1438-4639x 1618-131X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-6745
8564 8u https://doi.org/10.1016/j.ijheh.2013.12.001

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