WFRF:(Torkzad Michael)
Sökning: WFRF:(Torkzad Michael) > (2015-2019) > Cytoreductive surge...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04449naa a2200529 4500 | |
| 001 | oai:DiVA.org:uu-280096 | |
| 003 | SwePub | |
| 008 | 160308s2016 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:9e3db24c-b11e-49f1-88ad-91783d224a90 | |
| 009 | oai:prod.swepub.kib.ki.se:132854040 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2800962 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ejca.2015.09.0172 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/85924532 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1328540402 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cashin, Peter H.u Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)pecas623 |
| 245 | 1 0 | a Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases :b A randomised trial |
| 264 | 1 | b Elsevier BV,c 2016 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: First-line treatment of isolated resectable colorectal peritoneal metastases remains unclear. This study (the Swedish peritoneal study) compares cytoreductive surgery and intraperitoneal chemotherapy (surgery arm) with systemic chemotherapy (chemotherapy arm). Methods: Patients deemed resectable preoperatively were randomised to surgery and intraperitoneal 5-fluorouracil 550 mg/m(2) /d for 6 d with repeated courses every month or to systemic oxaliplatin and 5-fluorouracil regimen every second week. Both treatments continued for 6 months. Primary end-point was overall survival (OS) and secondary end-points were progression-free survival (PFS), and morbidity. Results: The study terminated prematurely when 48 eligible patients (24/arm) were included due to recruitment difficulties. Two-year OS was 54% in the surgery arm and 38% in the chemotherapy arm (p = 0.04). After 5 years, 8 versus 1 patient were alive, respectively (p = 0.02). Median OS was 25 months versus 18 months, respectively, hazard ratio 0.51 (95% confidence interval: 0.27-0.96, p = 0.04). PFS in the surgery arm was 12 months versus 11 months in the chemotherapy arm (p = 0.16) with 17% versus 0% 5-year PFS. Grade III-IV morbidity was seen in 42% and 50% of the patients, respectively. No mortalities. Conclusions: Cytoreductive surgery with intraperitoneal chemotherapy may be superior to systemic oxaliplatin-based treatment of colorectal cancer with resectable isolated peritoneal metastases.(ClinicalTrials. gov nr: NCT01524094). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Cytoreductive surgery | |
| 653 | a Intraperitoneal chemotherapy | |
| 653 | a Colorectal cancer | |
| 653 | a Systemic chemotherapy | |
| 653 | a Peritoneal metastases | |
| 653 | a Peritoneal carcinomatosis | |
| 700 | 1 | a Mahteme, Haileu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Canc Clin, Uppsala, Sweden.4 aut0 (Swepub:uu)hailmaht |
| 700 | 1 | a Spang, N.u Uppsala universitet,Institutionen för kirurgiska vetenskaper4 aut |
| 700 | 1 | a Syk, Ingvaru Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-isy |
| 700 | 1 | a Frodin, J. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Torkzad, Michaelu Uppsala universitet,Radiologi4 aut |
| 700 | 1 | a Glimelius, Bengtu Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Pathol & Oncol, S-17176 Stockholm, Sweden.4 aut0 (Swepub:uu)bengglim |
| 700 | 1 | a Graf, Wilhelmu Uppsala universitet,Kolorektalkirurgi4 aut0 (Swepub:uu)wilhgraf |
| 710 | 2 | a Uppsala universitetb Kolorektalkirurgi4 org |
| 773 | 0 | t European Journal of Cancerd : Elsevier BVg 53, s. 155-162q 53<155-162x 0959-8049x 1879-0852 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26751236?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1016/j.ejca.2015.09.017y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280096 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ejca.2015.09.017 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/8592453 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132854040 |
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