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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004915naa a2200481 4500
001oai:lup.lub.lu.se:f9814373-6038-4802-be1f-18f305cf9c19
003SwePub
008221020s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/f9814373-6038-4802-be1f-18f305cf9c192 URI
0247 a https://doi.org/10.1038/s42003-022-03559-72 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bjørklund, Sunniva Stordalu Oslo university hospital,Norwegian Radium Hospital4 aut
2451 0a Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
264 c 2022-08-18
264 1b Springer Science and Business Media LLC,c 2022
520 a Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered three distinct clusters of lncRNAs. In silico cell type deconvolution coupled with single-cell RNA-seq analyses revealed that these three clusters were driven by cell type specific expression of lncRNAs. In one cluster lncRNAs were expressed by cancer cells and were mostly associated with the estrogen signaling pathways. In the two other clusters, lncRNAs were expressed either by immune cells or fibroblasts of the tumor microenvironment. To further investigate the cis-regulatory regions driving lncRNA expression in breast cancer, we identified subtype-specific transcription factor (TF) occupancy at lncRNA promoters. We also integrated lncRNA expression with DNA methylation data to identify long-range regulatory regions for lncRNA which were validated using ChiA-Pet-Pol2 loops. lncRNAs play an important role in shaping the gene regulatory landscape in breast cancer. We provide a detailed subtype and cell type-specific expression of lncRNA, which improves the understanding of underlying transcriptional regulation in breast cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Aure, Miriam Ragleu Norwegian Radium Hospital,Oslo university hospital4 aut
7001 a Häkkinen, Jariu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)thep-jha
7001 a Vallon-Christersson, Johanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)onk-jvc
7001 a Kumar, Surendrau Norwegian Radium Hospital,Memorial University of Newfoundland4 aut
7001 a Evensen, Katrine Bullu Norwegian Radium Hospital4 aut
7001 a Fleischer, Thomasu Norwegian Radium Hospital4 aut
7001 a Tost, Jörgu University of Paris-Saclay4 aut
7001 a Sahlberg, Kristine K.u Oslo university hospital,Norwegian Radium Hospital4 aut
7001 a Mathelier, Anthonyu Oslo university hospital,University of Oslo4 aut
7001 a Bhanot, Gyanu Rutgers University: The State University of New Jersey,Rutgers Cancer Institute of New Jersey4 aut
7001 a Ganesan, Shridaru Rutgers Cancer Institute of New Jersey4 aut
7001 a Tekpli, Xavieru Norwegian Radium Hospital,Oslo university hospital4 aut
7001 a Kristensen, Vessela N.u Oslo university hospital,University of Oslo4 aut
7102 a Oslo university hospitalb Norwegian Radium Hospital4 org
7102 a OSBREAC
7730 t Communications Biologyd : Springer Science and Business Media LLCg 5:1q 5:1x 2399-3642
8564 u http://dx.doi.org/10.1038/s42003-022-03559-7x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/f9814373-6038-4802-be1f-18f305cf9c19
8564 8u https://doi.org/10.1038/s42003-022-03559-7

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