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Probing the coverag...
Probing the coverage of nanoparticles by biomimetic membranes through nanoplasmonics
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- Cardellini, Jacopo (författare)
- University of Florence
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- Ridolfi, Andrea (författare)
- University of Florence,Vrije Universiteit Amsterdam,CNR Institute of nanostructured materials (ISMN-CNR)
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- Donati, Melissa (författare)
- University of Florence
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- Giampietro, Valentina (författare)
- University of Florence
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- Severi, Mirko (författare)
- University of Florence
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- Brucale, Marco (författare)
- CNR Institute of nanostructured materials (ISMN-CNR),University of Florence
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- Valle, Francesco (författare)
- CNR Institute of nanostructured materials (ISMN-CNR),University of Florence
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- Bergese, Paolo (författare)
- University of Brescia,University of Florence
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- Montis, Costanza (författare)
- University of Florence
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- Caselli, Lucrezia (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,University of Florence
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- Berti, Debora (författare)
- University of Florence
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska 10 s.
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797. ; 640, s. 100-109
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Although promising for biomedicine, the clinical translation of inorganic nanoparticles (NPs) is limited by low biocompatibility and stability in biological fluids. A common strategy to circumvent this drawback consists in disguising the active inorganic core with a lipid bilayer coating, reminiscent of the structure of the cell membrane to redefine the chemical and biological identity of NPs. While recent reports introduced membrane-coating procedures for NPs, a robust and accessible method to quantify the integrity of the bilayer coverage is not yet available. To fill this gap, we prepared SiO2 nanoparticles (SiO2NPs) with different membrane coverage degrees and monitored their interaction with AuNPs by combining microscopic, scattering, and optical techniques. The membrane-coating on SiO2NPs induces spontaneous clustering of AuNPs, whose extent depends on the coating integrity. Remarkably, we discovered a linear correlation between the membrane coverage and a spectral descriptor for the AuNPs’ plasmonic resonance, spanning a wide range of coating yields. These results provide a fast and cost-effective assay to monitor the compatibilization of NPs with biological environments, essential for bench tests and scale-up. In addition, we introduce a robust and scalable method to prepare SiO2NPs/AuNPs hybrids through spontaneous self-assembly, with a high-fidelity structural control mediated by a lipid bilayer.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
Nyckelord
- Biomimetic nanoparticles
- Extracellular vesicles
- Gold nanoparticles
- Membrane-coated nanoparticles
- Nano-bio interface
- Nanomedicine
- Nanoplasmonics
- Silica nanoparticles
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Cardellini, Jaco ...
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Ridolfi, Andrea
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Donati, Melissa
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Giampietro, Vale ...
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Severi, Mirko
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Brucale, Marco
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visa fler...
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Valle, Francesco
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Bergese, Paolo
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Montis, Costanza
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Caselli, Lucrezi ...
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Berti, Debora
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Nanoteknik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Atom och molekyl ...
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Journal of Collo ...
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Lunds universitet