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Sökning: WFRF:(Van Moorselaar Jeroen) > miR-129-3p controls...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003605naa a2200529 4500
001oai:DiVA.org:umu-121485
003SwePub
008160602s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1214852 URI
0247 a https://doi.org/10.18632/oncotarget.75722 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bijnsdorp, Irene V.4 aut
2451 0a miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110
264 c 2016-02-23
264 1b Impact Journals, LLC,c 2016
338 a electronic2 rdacarrier
520 a The centrosome plays a key role in cancer invasion and metastasis. However, it is unclear how abnormal centrosome numbers are regulated when prostate cancer (PCa) cells become metastatic. CP110 was previously described for its contribution of centrosome amplification (CA) and early development of aggressive cell behaviour. However its regulation in metastatic cells remains unclear. Here we identified miR-129-3p as a novel metastatic microRNA. CP110 was identified as its target protein. In PCa cells that have metastatic capacity, CP110 expression was repressed by miR-129-3p. High miR-129-3p expression levels increased cell invasion, while increasing CP110 levels decreased cell invasion. Overexpression of CP110 in metastatic PCa cells resulted in a decrease in the number of metastasis. In tissues of PCa patients, low CP110 and high miR-129-3p expression levels correlated with metastasis, but not with the expression of genes related to EMT. Furthermore, overexpression of CP110 in metastatic PCa cells resulted in excessive-CA (E-CA), and a change in F-actin distribution which is in agreement with their reduced metastatic capacity. Our data demonstrate that miR-129-3p functions as a CA gatekeeper in metastatic PCa cells by maintaining pro-metastatic centrosome amplification (CA) and preventing anti-metastatic E-CA.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a prostate cancer
653 a centrosome
653 a CP110
653 a miR-129-3p
653 a metastasis
7001 a Hodzic, Jasmina4 aut
7001 a Lagerweij, Tonny4 aut
7001 a Westerman, Bart4 aut
7001 a Krijgsman, Oscar4 aut
7001 a Broeke, Jurjen4 aut
7001 a Verweij, Frederik4 aut
7001 a Nilsson, R. Jonas A.u Umeå universitet,Onkologi,Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands4 aut0 (Swepub:umu)joni0002
7001 a Rozendaal, Lawrence4 aut
7001 a van Beusechem, Victor W.4 aut
7001 a van Moorselaar, Jeroen A.4 aut
7001 a Wurdinger, Thomas4 aut
7001 a Geldof, Albert A.4 aut
7102 a Umeå universitetb Onkologi4 org
7730 t Oncotargetd : Impact Journals, LLCg 7:13, s. 16676-16687q 7:13<16676-16687x 1949-2553
8564 u https://doi.org/10.18632/oncotarget.7572y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:938896/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7572&path%5B%5D=21998
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-121485
8564 8u https://doi.org/10.18632/oncotarget.7572

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