Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: Results from the MORGAM Consortium

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Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality : Results from the MORGAM Consortium

Morseth, Bente (author): School of Sport Sciences, UiT the Arctic University of Norway, Tromsø, Norway

Geelhoed, Bastiaan (author): Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany

Linneberg, Allan (author): Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Johansson, Lars (author): Umeå universitet,Avdelningen för medicin

Kuulasmaa, Kari (author): Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland

Salomaa, Veikko (author): Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland

Iacoviello, Licia (author): Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy; Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy

Costanzo, Simona (author): Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli (IS), Italy

Söderberg, Stefan (author): Umeå universitet,Avdelningen för medicin

Niiranen, Teemu J. (author): Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland

Vishram-Nielsen, Julie K. K. (author): Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Njølstad, Inger (author): Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway

Wilsgaard, Tom (author): Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway

Mathiesen, Ellisiv B. (author): Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway; Department of Neurology, University Hospital of North Norway, Tromsø, Norway

Løchen, Maja-Lisa (author): Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway

Zeller, Tanja (author): Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

Blankenberg, Stefan (author): Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

Ojeda, Francisco M. (author): Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany

Schnabel, Renate B. (author): Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany

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2021-08-02
2021
English.
In: Open heart. - : BMJ Publishing Group Ltd. - 2053-3624. ; 8:2

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://openheart.bm...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.Methods We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.Results AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).Conclusion In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality : Results from the MORGAM Consortium

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