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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003295naa a2200409 4500
001oai:lup.lub.lu.se:0a6e00d6-09fc-47b3-bf49-df0a36ffae5b
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/24162842 URI
0247 a https://doi.org/10.2337/dc11-13282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Delahanty, Linda M.4 aut
2451 0a Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program
264 c 2012-01-16
264 1b American Diabetes Association,c 2012
520 a OBJECTIVE-We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight-loss inducing interventions (lifestyle and metformin) versus placebo. RESEARCH DESIGN AND METHODS-Sixteen obesity-predisposing single nucleotide polymorphisms (SNPs) were tested for association with short-term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end). RESULTS-Irrespective of treatment, the Ala12 allele at PPARG associated with short- and long-term weight loss (-0.63 and -0.93 kg/allele, P <= 0.005, respectively). Gene-treatment interactions were observed for short-term (LYPLAL1 rs2605100, P-lifestyle*SNP = 0.032; GNPDA2 rs10938397, P-lifestyle*SNP = 0.016; MTCH2 rs10838738, P-lifestyle*SNP = 0.022) and long-term (NEGR1 rs2815752, P-metformin*SNP = 0.028; FTO rs9939609, P-lifestyle*SNP = 0.044) weight loss. Three of 16 SNPs were associated with weight regain (NEGR1 rs2815752, BDNF rs6265, PPARG rs1801282), irrespective of treatment. TMEM18 rs6548238 and KTCD15 rs29941 showed treatment-specific effects (P-lifestyle*SNP < 0.05). CONCLUSIONS-Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Pan, Qing4 aut
7001 a Jablonski, Icatiileen A.4 aut
7001 a Watson, Karol E.4 aut
7001 a McCaffery, Jeanne M.4 aut
7001 a Shuldiner, Alan4 aut
7001 a Kahn, Steven E.4 aut
7001 a Knowler, William C.4 aut
7001 a Florez, Jose C.4 aut
7001 a Franks, Paulu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7102 a Genetisk och molekylär epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t Diabetes Cared : American Diabetes Associationg 35:2, s. 363-366q 35:2<363-366x 1935-5548x 0149-5992
8564 u http://dx.doi.org/10.2337/dc11-1328y FULLTEXT
8564 u https://care.diabetesjournals.org/content/diacare/35/2/363.full.pdf
8564 8u https://lup.lub.lu.se/record/2416284
8564 8u https://doi.org/10.2337/dc11-1328

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