WFRF:(Xuan S)
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Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.
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- Simonsson, Ulrika S H (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
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- Jansson, Britt (author)
- Uppsala universitet,Avdelningen för farmakokinetik och läkemedelsterapi
- Hai, Trinh Ngoc (author)
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- Huong, Dinh Xuan (author)
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- (creator_code:org_t)
- 2003
- 2003
- English.
- In: Clinical pharmacology and therapeutics. - 0009-9236 .- 1532-6535. ; 74:1, s. 32-43
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Our goal was to investigate whether artemisinin autoinduction is caused by an increase in cytochrome P450 (CYP) 2B6 or CYP2C9 activities, we evaluated the effects of multiple-dose artemisinin administration on S-mephenytoin N-demethylation in healthy subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Adult
- Area Under Curve
- Artemisinins
- administration & dosage
- metabolism
- Aryl Hydrocarbon Hydroxylases
- biosynthesis
- genetics
- Confidence Intervals
- Enzyme Induction
- drug effects
- physiology
- Humans
- Male
- Mixed Function Oxygenases
- biosynthesis
- genetics
- Oxidoreductases
- N-Demethylating
- Phenotype
- Sesquiterpenes
- administration & dosage
- metabolism
- PHARMACY
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Tybring, Gunnel
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- MEDICAL AND HEALTH SCIENCES
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- By the university
- University of Gothenburg
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- Karolinska Institutet
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