Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Neurovetenskaper) > NRF2 is essential f...
Fältnamn | Indikatorer | Metadata |
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000 | 09100naa a2200877 4500 | |
001 | oai:gup.ub.gu.se/332281 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:68b87dd7-6d94-44ef-b980-d1a9caf6904c | |
009 | oai:DiVA.org:his-23363 | |
024 | 7 | a https://gup.ub.gu.se/publication/3322812 URI |
024 | 7 | a https://doi.org/10.1016/j.redox.2023.1029512 DOI |
024 | 7 | a https://research.chalmers.se/publication/5383172 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-233632 URI |
040 | a (SwePub)gud (SwePub)cthd (SwePub)his | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bauzá-Thorbrügge, Marcou Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden4 aut0 (Swepub:gu)xbauzm |
245 | 1 0 | a NRF2 is essential for adaptative browning of white adipocytes. |
264 | 1 | b Elsevier,c 2023 |
500 | a CC BY 4.0 DEED© 2023 The AuthorsCorrespondence Address: I. Wernstedt Asterholm; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Medicinaregatan 11, PO Box 432, SE, 405 30, Sweden; email: IWA@neuro.gu.se | |
520 | a White adipose tissue browning, defined by accelerated mitochondrial metabolism and biogenesis, is considered a promising mean to treat or prevent obesity-associated metabolic disturbances. We hypothesize that redox stress acutely leads to increased production of reactive oxygen species (ROS), which activate electrophile sensor nuclear factor erythroid 2-Related Factor 2 (NRF2) that over time results in an adaptive adipose tissue browning process. To test this, we have exploited adipocyte-specific NRF2 knockout mice and cultured adipocytes and analyzed time- and dose-dependent effect of NAC and lactate treatment on antioxidant expression and browning-like processes. We found that short-term antioxidant treatment with N-acetylcysteine (NAC) induced reductive stress as evident from increased intracellular NADH levels, increased ROS-production, reduced oxygen consumption rate (OCR), and increased NRF2 levels in white adipocytes. In contrast, and in line with our hypothesis, longer-term NAC treatment led to a NRF2-dependent browning response. Lactate treatment elicited similar effects as NAC, and mechanistically, these NRF2-dependent adipocyte browning responses in vitro were mediated by increased heme oxygenase-1 (HMOX1) activity. Moreover, this NRF2-HMOX1 axis was also important for β3-adrenergic receptor activation-induced adipose tissue browning in vivo. In conclusion, our findings show that administration of exogenous antioxidants can affect biological function not solely through ROS neutralization, but also through reductive stress. We also demonstrate that NRF2 is essential for white adipose tissue browning processes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
653 | a Mice | |
653 | a Animals | |
653 | a Adipocytes | |
653 | a White | |
653 | a metabolism | |
653 | a NF-E2-Related Factor 2 | |
653 | a genetics | |
653 | a metabolism | |
653 | a Antioxidants | |
653 | a pharmacology | |
653 | a metabolism | |
653 | a Reactive Oxygen Species | |
653 | a metabolism | |
653 | a Adipose Tissue | |
653 | a White | |
653 | a metabolism | |
653 | a Acetylcysteine | |
653 | a pharmacology | |
653 | a Lactates | |
653 | a metabolism | |
653 | a Redox stress | |
653 | a Translationell medicin TRIM | |
700 | 1 | a Peris Franquet, Eduardu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden4 aut0 (Swepub:gu)xpered |
700 | 1 | a Zamani, Shabnamu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden4 aut |
700 | 1 | a Micallef, Peter,d 1988u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden4 aut0 (Swepub:gu)xmicpe |
700 | 1 | a Paul, Alexandra,d 1988u The University of Texas at Austin, USA,Chalmers tekniska högskola,Chalmers University of Technology,Department of Biology and Biological Engineering, Division of Chemical Biology, Chalmers University of Technology, Gothenburg, Sweden ; The Department of Biomedical Engineering, University of Texas at Austin, TX, United States4 aut0 (Swepub:cth)apaul |
700 | 1 | a Bartesaghi, Stefanou AstraZeneca AB,Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden4 aut |
700 | 1 | a Benrick, Anna,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Högskolan i Skövde,University of Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine TRIM4 aut0 (Swepub:his)benb |
700 | 1 | a Wernstedt Asterholm, Ingrid,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg,Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Sweden4 aut0 (Swepub:gu)xwerni |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
773 | 0 | t Redox biologyd : Elsevierg 68q 68x 2213-2317 |
856 | 4 | u https://research.chalmers.se/publication/538317/file/538317_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.redox.2023.102951y Fulltext |
856 | 4 | u https://his.diva-portal.org/smash/get/diva2:1812418/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/332281 |
856 | 4 8 | u https://doi.org/10.1016/j.redox.2023.102951 |
856 | 4 8 | u https://research.chalmers.se/publication/538317 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23363 |
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