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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03554naa a2200313 4500 | |
| 001 | oai:DiVA.org:liu-23882 | |
| 003 | SwePub | |
| 008 | 091007s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-238822 URI |
| 024 | 7 | a https://doi.org/10.1016/j.freeradbiomed.2003.11.0222 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bergman, Vivi4 aut |
| 245 | 1 0 | a Urinary excretion of 8-hydroxydeoxyguanosine and malondialdehyde after high dose radiochemotherapy preceding stem cell transplantation |
| 264 | 1 | b Elsevier BV,c 2004 |
| 338 | a print2 rdacarrier | |
| 520 | a The urinary excretion of the hydroxylated DNA base 8-hydroxydeoxyguanosine (8-OHdG) and the lipid peroxidation product malondialdehyde (MDA) was monitored in 11 patients with hematological malignancies undergoing total body irradiation and high-dose chemotherapy preceding bone marrow transplantation. Nine patients showed a prompt increase in urinary 8-OHdG (8-25 times the initial baseline level) on days 0-7 after irradiation onset, the excretion then decreased during the aplastic period and increased again when engraftment took place (in 7 patients). A significant positive correlation was found between urinary 8-OHdG and whole blood leukocyte count, both on day 5 (p = .04, r = .72) and on day 22 (p = .009, r = .80) after irradiation onset. One patient who lacked the first peak of 8-OHdG excretion showed low blood leukocyte counts (less than 2×109/l) before therapy onset, this patient, however, later had a successful engraftment and then also showed considerable increases in both 8-OHdG excretion and leukocyte count. These observations suggest leukocytes play a part in the excretion of 8-OHdG after conditioning therapy preceding bone marrow transplantation. As opposed to the biphasic 8-OHdG excretion, the excretion of MDA showed a single peak appearing on days 11-19 after radiochemotherapy onset, i.e., during the period in which the patients suffered from cytopenia, mucositis, and other side effects of the treatment. It is suggested, therefore, that these clinical manifestations are associated with increased lipid peroxidation. Altogether, these findings illustrate the utility of serial urinary samples for monitoring oxidative stress due to conditioning therapy in clinical practice. They also demonstrate that different oxidative stress markers may behave quite differently regarding their appearance in the urine after whole-body oxidative stress. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Leanderson, Per,d 1958-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum4 aut0 (Swepub:liu)perle80 |
| 700 | 1 | a Starkhammar, Hans,d 1948-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US4 aut0 (Swepub:liu)hanst87 |
| 700 | 1 | a Tagesson, Christer,d 1948-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin,Yrkes- och miljömedicinskt centrum4 aut0 (Swepub:liu)chrta55 |
| 710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
| 773 | 0 | t Free Radical Biology & Medicined : Elsevier BVg 36:3, s. 300-306q 36:3<300-306x 0891-5849x 1873-4596 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-23882 |
| 856 | 4 8 | u https://doi.org/10.1016/j.freeradbiomed.2003.11.022 |
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