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Molecular Response ...
Molecular Response to Nanopatterned Implants in the Human Jaw Bone
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- Karazisis, Dimitrios, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg, Sweden,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
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- Omar, O. (författare)
- Imam Abdulrahman Bin Faisal University, Saudi Arabia,Imam Abdulrahman bin Faisal Univ, Saudi Arabia
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- Petronis, Sarunas (författare)
- RISE,Metodik för produktframtagning,RISE Res Inst Sweden, Sweden
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- Thomsen, Peter, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg, Sweden,Univ Gothenburg, Sweden
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- Rasmusson, Lars, 1962 (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institutionen för odontologi, sektion 1,Institute of Clinical Sciences, Department of Biomaterials,Institute of Odontology, Section 1,University of Gothenburg, Sweden; Linköping University Hospital, Sweden,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Käkkliniken US,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
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(creator_code:org_t)
- 2021-12-01
- 2021
- Engelska.
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Ingår i: Acs Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 7:12, s. 5878-5889
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Abstract
Ämnesord
Stäng
- Implant surface modification by nanopatterning is an interesting route for enhancing osseointegration in humans. Herein, the molecular response to an intentional, controlled nanotopography pattern superimposed on screw-shaped titanium implants is investigated in human bone. When clinical implants are installed, additional two mini-implants, one with a machined surface (M) and one with a machined surface superimposed with a hemispherical nanopattern (MN), are installed in the posterior maxilla. In the second-stage surgery, after 6-8 weeks, the mini-implants are retrieved by unscrewing, and the implant-adherent cells are subjected to gene expression analysis using quantitative polymerase chain reaction (qPCR). Compared to those adherent to the machined (M) implants, the cells adherent to the nanopatterned (MN) implants demonstrate significant upregulation (1.8- to 2-fold) of bone-related genes (RUNX2, ALP, and OC). No significant differences are observed in the expression of the analyzed inflammatory and remodeling genes. Correlation analysis reveals that older patient age is associated with increased expression of proinflammatory cytokines (TNF-alpha and MCP-1) on the machined implants and decreased expression of proosteogenic factor (BMP-2) on the nanopatterned implants. Controlled nanotopography, in the form of hemispherical 60 nm protrusions, promotes gene expressions related to early osteogenic differentiation and osteoblastic activity in implant-adherent cells in the human jaw bone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- osseointegration
- nanomedicine
- nanotopography
- gene expression
- osteogenic activities
- human jaw
- well-defined nanotopography
- titanium-dioxide nanotubes
- gene-expression
- follow-up
- in-vivo
- different diameters
- dental
- implants
- tio2 nanotubes
- osseointegration
- surfaces
- Materials Science
- gene expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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