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Bis 4,5-diazafluore...
Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening
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- Massoud, Al-Shimaà A A, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gohar, Y. M. (författare)
- Alexandria University
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- Langer, Vratislav, 1949 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Lincoln, Per, 1958 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Svensson, Frida, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Janis, J. (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Gårdebjer, Sofie, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Mölnlycke healthcare
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- Haukka, M. (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Jonsson, Fabian, 1983 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Aneheim, Emma, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Löwenhielm, Peter (författare)
- Mölnlycke healthcare
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- Abu-Youssef, Morsy A. M. (författare)
- Alexandria University
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- Öhrström, Lars, 1963 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa färre...
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(creator_code:org_t)
- Royal Society of Chemistry (RSC), 2011
- 2011
- Engelska.
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Ingår i: New Journal of Chemistry. - : Royal Society of Chemistry (RSC). - 1369-9261 .- 1144-0546. ; 35:3, s. 640-648
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Abstract
Ämnesord
Stäng
- Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)2NO3], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)2]NO3 . H2O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)o. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0o. Compound I was characterized by 1H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml-1, respectively). Three different hydrogels containing I or Ag2SO4 were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- zn-ii
- bonding complexes
- metal-complexes
- fe-iii
- deoxyribonucleic acid
- crystal-structures
- cu-ii
- ag-i
- antimicrobial activity
- ag(i) complexes
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- art (ämneskategori)
- ref (ämneskategori)
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Massoud, Al-Shim ...
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Gohar, Y. M.
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Langer, Vratisla ...
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Lincoln, Per, 19 ...
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Svensson, Frida, ...
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Janis, J.
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visa fler...
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Gårdebjer, Sofie ...
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Haukka, M.
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Jonsson, Fabian, ...
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Aneheim, Emma, 1 ...
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Löwenhielm, Pete ...
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Abu-Youssef, Mor ...
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Öhrström, Lars, ...
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