Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: Rationale and design of the EURO-ICE trial

El Farissi, MohamedDepartment of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)

Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction : Rationale and design of the EURO-ICE trial

Funding Agency:Abbott Laboratories
In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect.Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.

Keulards, Danielle C. J.Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
van 't Veer, MarcelDepartment of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
Zelis, Jo M.Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
Berry, ColinDepartment of Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom (författare)
De Bruyne, BernardCardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (författare)
Engstrøm, ThomasDepartment of Cardiology, Rigshospitalet, Copenhagen, Denmark (författare)
Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology(Swepub:oru)oft (författare)
Piroth, ZsolthDepartment of Adult Cardiology, Hungarian Institute of Cardiology, Budapest, Hungary (författare)
Oldroyd, Keith G.Department of Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom (författare)
Tonino, Pim A. L.Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
Pijls, Nico H. J.Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
Otterspoor, Luuk C.Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (författare)
Department of Cardiology, Catharina Hospital, Eindhoven, The NetherlandsDepartment of Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom (creator_code:org_t)

Ingår i:EuroIntervention: European Society of Cardiology16:17, s. 1444-14461774-024X1969-6213

Av författaren/redakt...: El Farissi, Moha ...; Keulards, Daniel ...; van 't Veer, Mar ...; Zelis, Jo M.; Berry, Colin; De Bruyne, Berna ...; visa fler...; Engstrøm, Thomas; Fröbert, Ole, 19 ...; Piroth, Zsolth; Oldroyd, Keith G ...; Tonino, Pim A. L ...; Pijls, Nico H. J ...; Otterspoor, Luuk ...; visa färre...

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