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Probable role for m...
Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption
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- Bagchi, Sonchita, 1978- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Perland, Emelie (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Schiöth: Funktionell farmakologi
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- Hosseini, Kimia (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Lundgren, Johanna (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Al-Walai, Noura (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Kheder, Sania (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi
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- Fredriksson, Robert (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- 2020-01-06
- 2020
- Engelska.
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Ingår i: International Journal of Neuroscience. - : Informa UK Limited. - 0020-7454 .- 1563-5279 .- 1543-5245. ; 130:5, s. 476-489
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: The major facilitator superfamily (MFS) is known as the largest and most diverse superfamily containing human transporters, and these transporters are essential as they sustain the homeostasis within cellular compartments by moving substances over lipid membranes.Methods: We have identified a novel MFS protein, named Major facilitator superfamily domain containing 6 (MFSD6), and confirmed that it is phylogenetically related to the human Solute Carrier (SLC) transporter family. A homology model of MFSD6 revealed 12 predicted transmembrane segments (TMS) with the classical MFS fold between TMS 6 and 7.Results: Immunohistological analyses showed specific MFSD6 staining in neurons of wildtype mouse brain tissue, but no expression in astrocytes. Furthermore, we explored expression and probable function(s) of MFSD6 in relation to its phylogenetically related proteins, major facilitator superfamily domain containing 8 (MFSD8) and 10 (MFSD10), which is of interest as both these proteins are involved in diseases.Conclusions: We showed that expression levels of Mfsd6 and Mfsd10 were decreased with elevated or depleted energy consumption, while that of Mfsd8 remained unaffected.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Transporter
- energy metabolism
- genetics
- mRNA
- molecular imaging
- Major Facilitator Superfamily Domain containing 6 (MFSD6)
- human Solute Carrier (SLC) transporter family
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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