WFRF:(Geirsson H)
Sökning: WFRF:(Geirsson H) > Genetic variants as...
- 20 av 45
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03281naa a2200649 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147801993 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1478019932 URI |
| 024 | 7 | a https://doi.org/10.1038/s42003-021-02642-92 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mikaelsdottir, E4 aut |
| 245 | 1 0 | a Genetic variants associated with platelet count are predictive of human disease and physiological markers |
| 264 | c 2021-09-27 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Platelets play an important role in hemostasis and other aspects of vascular biology. We conducted a meta-analysis of platelet count GWAS using data on 536,974 Europeans and identified 577 independent associations. To search for mechanisms through which these variants affect platelets, we applied cis-expression quantitative trait locus, DEPICT and IPA analyses and assessed genetic sharing between platelet count and various traits using polygenic risk scoring. We found genetic sharing between platelet count and counts of other blood cells (except red blood cells), in addition to several other quantitative traits, including markers of cardiovascular, liver and kidney functions, height, and weight. Platelet count polygenic risk score was predictive of myeloproliferative neoplasms, rheumatoid arthritis, ankylosing spondylitis, hypertension, and benign prostate hyperplasia. Taken together, these results advance understanding of diverse aspects of platelet biology and how they affect biological processes in health and disease. | |
| 700 | 1 | a Thorleifsson, G4 aut |
| 700 | 1 | a Stefansdottir, L4 aut |
| 700 | 1 | a Halldorsson, G4 aut |
| 700 | 1 | a Sigurdsson, JK4 aut |
| 700 | 1 | a Lund, SH4 aut |
| 700 | 1 | a Tragante, V4 aut |
| 700 | 1 | a Melsted, P4 aut |
| 700 | 1 | a Rognvaldsson, S4 aut |
| 700 | 1 | a Norland, K4 aut |
| 700 | 1 | a Helgadottir, A4 aut |
| 700 | 1 | a Magnusson, MK4 aut |
| 700 | 1 | a Ragnarsson, GB4 aut |
| 700 | 1 | a Kristinsson, SY4 aut |
| 700 | 1 | a Reykdal, S4 aut |
| 700 | 1 | a Vidarsson, B4 aut |
| 700 | 1 | a Gudmundsdottir, IJ4 aut |
| 700 | 1 | a Olafsson, I4 aut |
| 700 | 1 | a Onundarson, PT4 aut |
| 700 | 1 | a Sigurdardottir, O4 aut |
| 700 | 1 | a Sigurdsson, EL4 aut |
| 700 | 1 | a Grondal, G4 aut |
| 700 | 1 | a Geirsson, AJ4 aut |
| 700 | 1 | a Geirsson, G4 aut |
| 700 | 1 | a Gudmundsson, J4 aut |
| 700 | 1 | a Holm, H4 aut |
| 700 | 1 | a Saevarsdottir, Su Karolinska Institutet4 aut |
| 700 | 1 | a Jonsdottir, I4 aut |
| 700 | 1 | a Thorgeirsson, G4 aut |
| 700 | 1 | a Gudbjartsson, DF4 aut |
| 700 | 1 | a Thorsteinsdottir, U4 aut |
| 700 | 1 | a Rafnar, T4 aut |
| 700 | 1 | a Stefansson, K4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Communications biologyd : Springer Science and Business Media LLCg 4:1, s. 1132-q 4:1<1132-x 2399-3642 |
| 856 | 4 | u https://www.nature.com/articles/s42003-021-02642-9.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147801993 |
| 856 | 4 8 | u https://doi.org/10.1038/s42003-021-02642-9 |
- 20 av 45
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Mikaelsdottir, E
- Thorleifsson, G
- Stefansdottir, L
- Halldorsson, G
- Sigurdsson, JK
- Lund, SH
- visa fler...
- Tragante, V
- Melsted, P
- Rognvaldsson, S
- Norland, K
- Helgadottir, A
- Magnusson, MK
- Ragnarsson, GB
- Kristinsson, SY
- Reykdal, S
- Vidarsson, B
- Gudmundsdottir, ...
- Olafsson, I
- Onundarson, PT
- Sigurdardottir, ...
- Sigurdsson, EL
- Grondal, G
- Geirsson, AJ
- Geirsson, G
- Gudmundsson, J
- Holm, H
- Saevarsdottir, S
- Jonsdottir, I
- Thorgeirsson, G
- Gudbjartsson, DF
- Thorsteinsdottir ...
- Rafnar, T
- Stefansson, K
- visa färre...
- Artiklar i publikationen
- Communications b ...
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
