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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009373naa a2200757 4500
001oai:DiVA.org:umu-191667
003SwePub
008220121s2022 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:6fd53ff2-c965-4093-b3a6-a533a67787b9
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1916672 URI
0247 a https://doi.org/10.1038/s41416-021-01697-z2 DOI
0247 a https://lup.lub.lu.se/record/6fd53ff2-c965-4093-b3a6-a533a67787b92 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mukama, Trasiasu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
2451 0a Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
264 c 2022-01-14
264 1b Springer Nature,c 2022
338 a electronic2 rdacarrier
520 a Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer.Results: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone.Conclusion: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Fortner, Renée Turzanskiu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Hynes, Lucas Coryu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Petrera, Agneseu Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany4 aut
7001 a Hauck, Stefanie M.u Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany4 aut
7001 a Johnson, Theronu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Schulze, Matthiasu Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany4 aut
7001 a Schiborn, Catarinau Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany4 aut
7001 a Rostgaard-Hansen, Agnetha Linnu Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark4 aut
7001 a Overvad, Kimu Department of Public Health, Aarhus University, Bartholins Alle 2, Aarhus C, Denmark4 aut
7001 a Pérez, María José Sánchezu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP)4 aut
7001 a Crous-Bou, Martau Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University,Bellvitge University Hospital-IDIBELL4 aut
7001 a Chirlaque, María-Doloresu CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain4 aut
7001 a Amiano, Pilaru CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain4 aut
7001 a Ardanaz, Evau CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain4 aut
7001 a Watts, Eleanor L.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Travis, Ruth C.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Sacerdote, Carlottau Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, Turin, Italy4 aut
7001 a Grioni, Sarau Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy4 aut
7001 a Masala, Giovannau Institute of Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy4 aut
7001 a Signoriello, Simonau Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy4 aut
7001 a Tumino, Rosariou Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy4 aut
7001 a Gram, Inger T.u Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Sandanger, Torkjel M.u Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Sartor, Hannau Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)med-hso
7001 a Lundin, Evau Umeå University,Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001
7001 a Idahl, Annika,d 1965-u Umeå University,Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002
7001 a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Dossus, Laureu Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
7001 a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7102 a Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germanyb Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany4 org
7730 t British Journal of Cancerd : Springer Natureg 126, s. 1301-1309q 126<1301-1309x 0007-0920x 1532-1827
8564 u https://doi.org/10.1038/s41416-021-01697-zy Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1630820/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41416-021-01697-z.pdf
8564 u http://dx.doi.org/10.1038/s41416-021-01697-zx freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191667
8564 8u https://doi.org/10.1038/s41416-021-01697-z
8564 8u https://lup.lub.lu.se/record/6fd53ff2-c965-4093-b3a6-a533a67787b9

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