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Search: WFRF:(Johansson Maria E I 1961) > Autism with ophthal...

Autism with ophthalmologic malformations: the plot thickens.

Miller, Marilyn T (author)
Strömland, Kerstin, 1934 (author)
Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för oftalmologi,Institute of Clinical Neurosciences, Section of Ophtalmology
Ventura, Liana (author)
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Johansson, Maria E I, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
Bandim, Jose M (author)
Gillberg, Christopher, 1950 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för barn- och ungdomspsykiatri,Institute for the Health of Women and Children, Dept of Child and Adolescent Psychiatry
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 (creator_code:org_t)
2004
2004
English.
In: Transactions of the American Ophthalmological Society. - 0065-9533. ; 102
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE: To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study. METHODS: In the Swedish CHARGE study, 31 patients met the inclusion criteria (3+ or 4 of the common characteristics of the CHARGE syndrome). The same team of investigators also evaluated 20 Swedish patients with Goldenhar syndrome. In the Brazilian Möbius study, 28 children with a diagnosis of Möbius sequence were studied; some children had a history of exposure during their mother's pregnancy to the abortifacient drug misoprostol in an unsuccessful abortion attempt. RESULTS: In the CHARGE study, five patients had the more severe autism disorder and five had autistic-like condition. In the Goldenhar study, two had autism disorder and one had autistic-like condition. In the Brazilian Möbius study, the systemic findings of the misoprostol-exposed and misoprostol-unexposed patients were almost undistinguishable, and ASD was present in both groups (autism disorder in five and autistic-like condition in three). CONCLUSION: Autism spectrum disorder has been reported in two conditions with known early pregnancy exposure to the teratogenic agents thalidomide and misoprostol. In the Brazilian Möbius study, autism also occurred in both the misoprostol-exposed and misoprostol-unexposed groups. Autism also was present in patients with both CHARGE association and Goldenhar syndrome.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

Abnormalities
Drug-Induced
Abnormalities
Multiple
Adolescent
Autistic Disorder
complications
psychology
Child
Child
Preschool
Eye Abnormalities
complications
Female
Goldenhar Syndrome
complications
Humans
Male
Misoprostol
adverse effects
Mobius Syndrome
chemically induced
complications
Severity of Illness Index
Teratogens
Thalidomide
adverse effects

Publication and Content Type

ref (subject category)
art (subject category)

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