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Sökning: WFRF:(Li Hao 1984 ) > (2020-2024) > Vascular Supply of ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003965naa a2200409 4500
001oai:DiVA.org:uu-421088
003SwePub
008201007s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4210882 URI
0247 a https://doi.org/10.1038/s41598-020-62653-02 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mei, Xueshuangu Uppsala universitet,Öron-, näs- och halssjukdomar,Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen, Peoples R China.4 aut
2451 0a Vascular Supply of the Human Spiral Ganglion :b Novel Three-Dimensional Analysis Using Synchrotron Phase-Contrast Imaging and Histology
264 c 2020-04-03
264 1b Springer Nature,c 2020
338 a electronic2 rdacarrier
500 a These authors share last authorship: Hanif M. Ladak, Sumit K. Agrawal and Helge Rask-Andersen.
520 a Human spiral ganglion (HSG) cell bodies located in the bony cochlea depend on a rich vascular supply to maintain excitability. These neurons are targeted by cochlear implantation (CI) to treat deafness, and their viability is critical to ensure successful clinical outcomes. The blood supply of the HSG is difficult to study due to its helical structure and encasement in hard bone. The objective of this study was to present the first three-dimensional (3D) reconstruction and analysis of the HSG blood supply using synchrotron radiation phase-contrast imaging (SR-PCI) in combination with histological analyses of archival human cochlear sections. Twenty-six human temporal bones underwent SR-PCI. Data were processed using volume-rendering software, and a representative three-dimensional (3D) model was created to allow visualization of the vascular anatomy. Histologic analysis was used to verify the segmentations. Results revealed that the HSG is supplied by radial vascular twigs which are separate from the rest of the inner ear and encased in bone. Unlike with most organs, the arteries and veins in the human cochlea do not follow the same conduits. There is a dual venous outflow and a modiolar arterial supply. This organization may explain why the HSG may endure even in cases of advanced cochlear pathology.
650 7a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk bildbehandling0 (SwePub)206032 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Image Processing0 (SwePub)206032 hsv//eng
7001 a Glueckert, Rudolfu Med Univ Innsbruck, Dept Otolaryngol, Anichstr 35, A-6020 Innsbruck, Austria.4 aut
7001 a Schrott-Fischer, Anneliesu Med Univ Innsbruck, Dept Otolaryngol, Anichstr 35, A-6020 Innsbruck, Austria.4 aut
7001 a Li, Hao,d 1984-u Uppsala universitet,Öron-, näs- och halssjukdomar4 aut0 (Swepub:uu)haoli805
7001 a Ladak, Hanif M.u Western Univ, Dept Med Biophys, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.4 aut
7001 a Agrawal, Sumit K.u Western Univ, Dept Elect & Comp Engn, London, ON, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.4 aut
7001 a Rask-Andersen, Helgeu Uppsala universitet,Öron-, näs- och halssjukdomar,Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.4 aut0 (Swepub:uu)helgraan
7102 a Uppsala universitetb Öron-, näs- och halssjukdomar4 org
7730 t Scientific Reportsd : Springer Natureg 10:1q 10:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-020-62653-0y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1473936/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-020-62653-0.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421088
8564 8u https://doi.org/10.1038/s41598-020-62653-0

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