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FältnamnIndikatorerMetadata
00003295naa a2200373 4500
001oai:prod.swepub.kib.ki.se:131240508
003SwePub
008240701s2015 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1312405082 URI
0247 a https://doi.org/10.1159/0003751642 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haugvik, SP4 aut
2451 0a Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis
264 c 2015-01-22
264 1b S. Karger AG,c 2015
520 a <b><i>Background and Aims:</i></b> Risk factors for pancreatic neuroendocrine tumors (PNETs) are not well understood. The aim of this systematic review was to assess if diabetes mellitus, smoking, alcohol use, and family history of cancer are risk factors for PNETs. <b><i>Methods:</i></b> MEDLINE and abstracts from the European and North American Neuroendocrine Tumor Societies (ENETS and NANETS) were searched for studies published until October 2013. Eligible studies were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. <b><i>Results:</i></b> Five studies evaluating 4 individual populations were included (study accrual period 2000-2011) into the meta-analysis, involving 827 cases (range 160-309 per study) and 2,407 controls (range 233-924 per study). All studies had a case-control design and described regional series. The pooled adjusted odds ratio was 2.74 (95% CI: 1.63-4.62; p < 0.01; I<sup>2</sup> = 60.4%) for history of diabetes, 1.21 (95% CI: 0.92-1.58; p = 0.18; I<sup>2</sup> = 45.8%) for ever smoking, 1.37 (95% CI: 0.99-1.91; p = 0.06; I<sup>2</sup> = 0.0%) for heavy smoking, 1.09 (95% CI: 0.64-1.85; p = 0.75; I<sup>2</sup> = 85.2%) for ever alcohol use, 2.72 (95% CI: 1.25-5.91; p = 0.01; I<sup>2</sup> = 57.8%) for heavy alcohol use, and 2.16 (95% CI: 1.64-2.85; p < 0.01; I<sup>2</sup> = 0.0%) for first-degree family history of cancer. <b><i>Conclusions:</i></b> Diabetes mellitus and first-degree family history of cancer are associated with an increased risk of sporadic PNET. There was also a trend for diagnosis of sporadic PNET associated with heavy smoking. Alcohol use may be a risk factor for PNET, but there was considerable heterogeneity in the meta-analysis. These results suggest the need for a larger, homogeneous, international study for the clarification of risk factors for the occurrence of PNET.
7001 a Hedenstrom, P4 aut
7001 a Korsaeth, E4 aut
7001 a Valente, Ru Karolinska Institutet4 aut
7001 a Hayes, A4 aut
7001 a Siuka, D4 aut
7001 a Maisonneuve, P4 aut
7001 a Gladhaug, IP4 aut
7001 a Lindkvist, B4 aut
7001 a Capurso, G4 aut
7102 a Karolinska Institutet4 org
7730 t Neuroendocrinologyd : S. Karger AGg 101:2, s. 133-142q 101:2<133-142x 1423-0194x 0028-3835
8564 u https://www.karger.com/Article/Pdf/375164
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131240508
8564 8u https://doi.org/10.1159/000375164

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