Sökning: WFRF:(Molinuevo Jose L.) > Primary fatty amide...
Fältnamn | Indikatorer | Metadata |
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000 | 12436naa a2201141 4500 | |
001 | oai:DiVA.org:oru-79153 | |
003 | SwePub | |
008 | 200114s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141071627 | |
009 | oai:gup.ub.gu.se/280954 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-791532 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2019.03.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410716272 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2809542 URI |
040 | a (SwePub)orud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kim, Minu Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut |
245 | 1 0 | a Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort |
264 | c 2019-05-08 | |
264 | 1 | b Elsevier,c 2019 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Innovative Medicines Initiative Joint Undertaking under EMIF, Grant number 115372European Union (EU), Appeared in article as European UnionEFPIA companies European Commission Joint Research Centre, Appeared in article as European Commission, Grant number QLRT-2001-245537670Department of Health of the Basque Government, Grant number 17.0.1.08.12.0000.2.454.01.41142.001.HUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA, Appeared in article as National Institutes of Health, Grant number R15-GM107864 | |
520 | a INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Amyloid | |
653 | a Biomarkers | |
653 | a Brain volume measurements | |
653 | a CSF | |
653 | a Cognitive function measurements | |
653 | a Dementia | |
653 | a EMIF-AD | |
653 | a Metabolomics | |
653 | a Tau | |
700 | 1 | a Snowden, Stuartu Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Suvitaival, Tommiu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut |
700 | 1 | a Ali, Ashfaqu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut |
700 | 1 | a Merkler, David Ju Department of Chemistry, University of South Florida, Tampa, FL, USA4 aut |
700 | 1 | a Ahmad, Tahminau Institute of Pharmaceutical Science, King's College London, London, UK4 aut |
700 | 1 | a Westwood, Sarahu Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Baird, Alisonu Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Proitsi, Petroulau Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK4 aut |
700 | 1 | a Nevado-Holgado, Alejou Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Hye, Abdulu Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut |
700 | 1 | a Bos, Isabelleu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
700 | 1 | a Vos, Stephanieu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
700 | 1 | a Vandenberghe, Riku University Hospital Leuven, Leuven, Belgium4 aut |
700 | 1 | a Teunissen, Charlotteu Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut |
700 | 1 | a Ten Kate, Marau Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut |
700 | 1 | a Scheltens, Philipu Department of Neurology, Alzheimer Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands4 aut |
700 | 1 | a Gabel, Silvyu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium4 aut |
700 | 1 | a Meersmans, Karenu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium4 aut |
700 | 1 | a Blin, Olivieru Service de Pharmacologie Clinique et Pharmacovigilance, Institut de Neurosciences des Systèmes, Aix Marseille University, APHM, INSERM, Marseille, France4 aut |
700 | 1 | a Richardson, Jillu Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK4 aut |
700 | 1 | a De Roeck, Ellenu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium4 aut |
700 | 1 | a Sleegers, Kristelu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Flanders, Belgium4 aut |
700 | 1 | a Bordet, Régisu University of Lille, INSERM, CHU, Degenerative and Vascular Cognitive Disorders, Lille, Lille, France4 aut |
700 | 1 | a Rami, Lorenau Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain4 aut |
700 | 1 | a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xketpe |
700 | 1 | a Tsolaki, Magdau First Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece4 aut |
700 | 1 | a Verhey, Fransu Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands4 aut |
700 | 1 | a Sala, Isabelu Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut |
700 | 1 | a Lléo, Albertou Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut |
700 | 1 | a Peyratout, Gwendolineu University Hospital of Lausanne, Lausanne, Switzerland4 aut |
700 | 1 | a Tainta, Mikelu CITA-Alzheimer Foundation, San Sebastian, Spain4 aut |
700 | 1 | a Johannsen, Peteru Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark4 aut |
700 | 1 | a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden4 aut0 (Swepub:oru)yfi |
700 | 1 | a Frölich, Lutzu Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany4 aut |
700 | 1 | a Dobricic, Valerijau Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany4 aut |
700 | 1 | a Engelborghs, Sebastiaanu Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium4 aut |
700 | 1 | a Frisoni, Giovanni Bu University of Geneva, Geneva, Switzerland4 aut |
700 | 1 | a Molinuevo, José Lu Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain4 aut |
700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwaand |
700 | 1 | a Popp, Juliusu University Hospital of Lausanne, Lausanne, Switzerland; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland4 aut |
700 | 1 | a Martinez-Lage, Pablou CITA-Alzheimer Foundation, San Sebastian, Spain4 aut |
700 | 1 | a Bertram, Larsu University of Lübeck, Lübeck, Germany4 aut |
700 | 1 | a Barkhof, Frederiku Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut |
700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Streffer, Johannesu Experimental Medicine, Janssen Pharmaceutical Companies, Beerse, Belgium4 aut |
700 | 1 | a Visser, Pieter Ju Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands4 aut |
700 | 1 | a Lovestone, Simonu Department of Psychiatry, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Legido-Quigley, Cristinau Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark4 aut |
710 | 2 | a Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmarkb Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK4 org |
773 | 0 | t Alzheimer's & Dementiad : Elsevierg 15:6, s. 817-827q 15:6<817-827x 1552-5260x 1552-5279 |
856 | 4 | u https://doi.org/10.1016/j.jalz.2019.03.004y Fulltext |
856 | 4 | u https://doi.org/10.1016/j.jalz.2019.03.004 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79153 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2019.03.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141071627 |
856 | 4 8 | u https://gup.ub.gu.se/publication/280954 |
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