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Metabolic signature...
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Kliemann, NathalieInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-04-30
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BioMed Central,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-183119
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183119URI
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https://doi.org/10.1186/s12916-021-01970-1DOI
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https://lup.lub.lu.se/record/a503afcf-9f9e-4795-953b-ab8150366613URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.Methods: Targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and 17 individuals from a single-arm pilot weight loss intervention (Intercept) were used in this analysis. Metabolic signatures of body size were first determined in discovery (N = 3029) and replication (N = 1297) sets among EPIC participants by testing the associations between 129 metabolites and body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) using linear regression models followed by partial least squares analyses. Conditional logistic regression models assessed the associations between the metabolic signatures with endometrial (N = 635 cases and 648 controls) and colorectal (N = 423 cases and 423 controls) cancer risk using nested case-control studies in EPIC. Pearson correlation between changes in the metabolic signatures and weight loss was tested among Intercept participants.Results: After adjustment for multiple comparisons, greater BMI, WC, and WHR were associated with higher levels of valine, isoleucine, glutamate, PC aa C38:3, and PC aa C38:4 and with lower levels of asparagine, glutamine, glycine, serine, lysoPC C17:0, lysoPC C18:1, lysoPC C18:2, PC aa C42:0, PC ae C34:3, PC ae C40:5, and PC ae C42:5. The metabolic signature of BMI (OR1-sd 1.50, 95% CI 1.30–1.74), WC (OR1-sd 1.46, 95% CI 1.27–1.69), and WHR (OR1-sd 1.54, 95% CI 1.33–1.79) were each associated with endometrial cancer risk. Risk of colorectal cancer was positively associated with the metabolic signature of WHR (OR1-sd: 1.26, 95% CI 1.07–1.49). In the Intercept study, a positive correlation was observed between weight loss and changes in the metabolic signatures of BMI (r = 0.5, 95% CI 0.06–0.94, p = 0.03), WC (r = 0.5, 95% CI 0.05–0.94, p = 0.03), and WHR (r = 0.6, 95% CI 0.32–0.87, p = 0.01).Conclusions: Obesity is associated with a distinct metabolic signature comprising changes in levels of specific amino acids and lipids which is positively associated with both colorectal and endometrial cancer and is potentially reversible following weight loss.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Viallon, VivianInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Murphy, NeilInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Beeken, Rebecca J.Leeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom; Department of Behavioural Science and Health, University College London, London, United Kingdom,Leeds School of Medicine
(författare)
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Rothwell, Joseph A.Health Across Generations team, Centre for Research in Epidemiology and Population Health (CESP), INSERM U1018, Villejuif, France; Gustave Roussy, Villejuif, France,Institut Gustave Roussy
(författare)
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Rinaldi, SabinaInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Assi, NadaInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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van Roekel, Eline H.Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands
(författare)
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Schmidt, Julie A.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
(författare)
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Borch, Kristin BenjaminsenDepartment of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromsø, Norway
(författare)
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Agnoli, ClaudiaEpidemiology and Prevention Unit. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
(författare)
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Rosendahl, Ann H.Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)onk-aro
(författare)
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Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-hso
(författare)
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Huerta, José MaríaCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark
(författare)
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Halkjær, JytteDanish Cancer Society Research Center, Copenhagen, Denmark
(författare)
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Bueno-de-Mesquita, BasDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
(författare)
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Gicquiau, AudreyInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Achaintre, DavidInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Aleksandrova, KrasimiraNutrition, Immunity and Metabolism Senior Scientist Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
(författare)
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Schulze, Matthias B.Institute of Nutritional Science, University of Potsdam, Potsdam, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
(författare)
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Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
(författare)
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Tsilidis, Konstantinos K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
(författare)
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Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
(författare)
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Panico, SalvatoreDipartimento di Medicin Clinica e Chirurgia, Frederico II Univeristy, Naples, Italy
(författare)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Fortner, Renée T.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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van Guelpen, BethanyUmeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99
(författare)
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Scalbert, AugustinInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Keun, Hector C.Cancer Metabolism and Systems Toxicology Group, Division of Cancer, Department of Surgery and Cancer, Imperial College, London, United Kingdom
(författare)
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Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
(författare)
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Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization, Lyon, France
(författare)
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International Agency for Research on Cancer, World Health Organization, Lyon, FranceLeeds Institute of Health Sciences, University of Leeds, Leeds, United Kingdom; Department of Behavioural Science and Health, University College London, London, United Kingdom
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Medicine: BioMed Central19:11741-7015
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Kliemann, Nathal ...
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Viallon, Vivian
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Murphy, Neil
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Beeken, Rebecca ...
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Rothwell, Joseph ...
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Rinaldi, Sabina
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visa fler...
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Assi, Nada
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van Roekel, Elin ...
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Schmidt, Julie A ...
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Borch, Kristin B ...
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Agnoli, Claudia
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Rosendahl, Ann H ...
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Sartor, Hanna
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Huerta, José Mar ...
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Tjønneland, Anne
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Halkjær, Jytte
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Bueno-de-Mesquit ...
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Gicquiau, Audrey
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Achaintre, David
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Aleksandrova, Kr ...
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Schulze, Matthia ...
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Heath, Alicia K.
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Tsilidis, Konsta ...
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Masala, Giovanna
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Panico, Salvator ...
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Kaaks, Rudolf
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Fortner, Renée T ...
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van Guelpen, Bet ...
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Dossus, Laure
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Scalbert, August ...
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Keun, Hector C.
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Travis, Ruth C.
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Jenab, Mazda
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Johansson, Matti ...
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Ferrari, Pietro
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Gunter, Marc J.
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