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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006937naa a2200769 4500
001oai:DiVA.org:uu-265697
003SwePub
008151102s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132122757
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2656972 URI
0247 a https://doi.org/10.5966/sctm.2015-00212 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1321227572 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Simonson, Oscar E.u Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.4 aut
2451 0a In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
264 c 2015-08-18
264 1b Oxford University Press (OUP),c 2015
338 a print2 rdacarrier
500 a De 2 första författarna delar förstaförfattarskapet.De 3 sista författarna delar sistaförfattarskapet.
520 a Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653 a Acute respiratory distress syndrome
653 a Pulmonary diseases
653 a Respiratory tract
653 a Stem cells
653 a Cell transplantation
653 a Bone marrow stromal cells
653 a Cellular therapy
653 a Clinical translation
7001 a Mougiakakos, Dimitriosu Univ Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany.4 aut
7001 a Heldring, Ninau Karolinska Institutet4 aut
7001 a Bassi, Giuliou Univ Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy.4 aut
7001 a Johansson, Henrik J.u Karolinska Institutet4 aut
7001 a Dalen, Magnusu Karolinska Institutet4 aut
7001 a Jitschin, Reginau Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.4 aut
7001 a Rodin, Sergeyu Karolinska Institutet4 aut
7001 a Corbascio, Matthiasu Karolinska Institutet4 aut
7001 a El Andaloussi, Samiru Karolinska Institutet4 aut
7001 a Wiklander, Oscar P. B.u Karolinska Institutet4 aut
7001 a Nordin, Joel Z.u Karolinska Institutet4 aut
7001 a Skog, Johanu Exosome Diagnost Inc, New York, NY USA.4 aut
7001 a Romain, Charlotteu Exosome Diagnost Inc, New York, NY USA.4 aut
7001 a Koestler, Tinau Exosome Diagnost Inc, New York, NY USA.4 aut
7001 a Johansson Hellgren, Lailau Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)lahel172
7001 a Schiller, Petteru Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)pesch021
7001 a Joachimsson, Per-Olofu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)pejoa103
7001 a Hägglund, Hansu Karolinska Institutet,Uppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.4 aut0 (Swepub:uu)hanha689
7001 a Mattsson, Mattiasu Uppsala universitet,Hematologi,Univ Uppsala Hosp, Dept Hematol, Uppsala, Sweden.4 aut0 (Swepub:uu)matma431
7001 a Lentio, Janne4 aut
7001 a Faridani, Omid R.u Ludwig Inst Canc Res, S-10401 Stockholm, Sweden.4 aut
7001 a Sandberg, Rickardu Karolinska Institutet4 aut
7001 a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors
7001 a Krampera, Maurou Univ Verona, Dept Med, Sect Hematol, Stem Cell Res Lab, I-37100 Verona, Italy.4 aut
7001 a Weiss, Daniel J.u Univ Vermont, Dept Med, Hlth Sci Res Facil, Burlington, VT USA.4 aut
7001 a Grinnemo, Karl-Henriku Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Vaccine & Gene Therapy Inst Florida, Ctr Dis Aging, Port St Lucie, FL USA.4 aut
7001 a Le Blanc, Katarinau Karolinska Institutet4 aut
7102 a Karolinska Inst, Dept Mol Med & Surg, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Cardiothorac Surg & Anesthesia, Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Lab Med, Karolinska Univ Hosp, Stockholm, Sweden.b Univ Erlangen Nurnberg, Dept Internal Med Hematol & Oncol, D-91054 Erlangen, Germany.4 org
7730 t Stem Cells Translational Medicined : Oxford University Press (OUP)g 4:10, s. 1199-1213q 4:10<1199-1213x 2157-6564x 2157-6580
8564 u https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdfdirect/10.5966/sctm.2015-0021
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265697
8564 8u https://doi.org/10.5966/sctm.2015-0021
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132122757

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