Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by epidermal growth factor receptor transactivation

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Fältnamn	Indikatorer	Metadata
000		03902naa a2200361 4500
001		oai:lup.lub.lu.se:2b1cd402-cedf-4e5c-9347-00b8b89720c1
003		SwePub
008		170324s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/2b1cd402-cedf-4e5c-9347-00b8b89720c12 URI
024	7	a https://doi.org/10.1111/bjd.148832 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Mohanty, T.u Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-tkm
245	1 0	a Saliva induces expression of antimicrobial peptides and promotes intracellular killing of bacteria in keratinocytes by epidermal growth factor receptor transactivation
264		c 2017-01-24
264	1	b Oxford University Press (OUP),c 2017
300		a 10 s.
520		a Background: Wounds in the oral cavity, constantly exposed to both saliva and bacteria, heal quickly without infection. Furthermore, during licking of skin wounds, saliva promotes wound healing and plays a role in keeping the wound free of infection. Objectives: To investigate whether saliva induces expression of antimicrobial peptides (AMPs) in human epidermal keratinocytes and whether saliva promotes clearance of intracellular bacteria in these cells. Methods: Expression of AMPs was investigated in the oral mucosa and ex vivo injured skin by immunohistochemistry. Human beta-defensin-3 expression was investigated in epidermal keratinocytes after saliva stimulation, using real-time polymerase chain reaction and immunofluorescence. Results: We found higher expression of AMPs in the oral mucosa than in the epidermis. Saliva accelerated the injury-induced expression of AMPs in human skin ex vivo and was a potent inducer of the expression of AMPs in epidermal keratinocytes. The expression of AMPs was induced by metalloproteinase-dependent epidermal growth factor receptor (EGFR) transactivation mediated by a salivary lipid. Saliva increased the intracellular clearance of Staphylococcus aureus in keratinocytes through EGFR activation. Conclusions: These findings suggest a previously unreported role of saliva in innate immunity and demonstrate for the first time that saliva induces gene expression in epidermal keratinocytes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
700	1	a Alberius, P.u Skåne University Hospital4 aut0 (Swepub:lu)derm-pal
700	1	a Schmidtchen, A.u Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)derm-asc
700	1	a Reiss, K.u University of Kiel4 aut
700	1	a Schröder, J. M.u University of Kiel4 aut
700	1	a Sørensen, O. E.u Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-oso
710	2	a Infektionsmedicinb Sektion III4 org
773	0	t British Journal of Dermatologyd : Oxford University Press (OUP)g 176:2, s. 403-412q 176:2<403-412x 0007-0963x 1365-2133
856	4	u http://dx.doi.org/10.1111/bjd.14883y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/2b1cd402-cedf-4e5c-9347-00b8b89720c1
856	4 8	u https://doi.org/10.1111/bjd.14883

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Av författaren/redakt...: Mohanty, T.; Alberius, P.; Schmidtchen, A.; Reiss, K.; Schröder, J. M.; Sørensen, O. E.

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