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Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
- Sun, HM (author)
-
- Ringdahl, Ulrika (author)
- Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH
- Homeister, JW (author)
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- Fay, WP (author)
- Engleberg, NC (author)
- Yang, AY (author)
- Rozek, LS (author)
- Wang, XX (author)
- Ginsburg, D (author)
- show less...
- (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2004
- 2004
- English.
- In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 305:5688, s. 1283-1286
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- Sun, HM
- Ringdahl, Ulrika
- Homeister, JW
- Fay, WP
- Engleberg, NC
- Yang, AY
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- Rozek, LS
- Wang, XX
- Sjöbring, Ulf
- Ginsburg, D
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- MEDICAL AND HEALTH SCIENCES
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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