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FältnamnIndikatorerMetadata
00004979naa a2200445 4500
001oai:DiVA.org:umu-221843
003SwePub
008240312s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:238395442
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2218432 URI
0247 a https://doi.org/10.1093/bjs/znae0372 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2383954422 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rask, Gunillau Umeå universitet,Patologi,Kirurgi4 aut0 (Swepub:umu)guarak02
2451 0a Immune cell infiltrate in ductal carcinoma in situ and the risk of dying from breast cancer :b case-control study
264 1b Oxford University Press,c 2024
338 a electronic2 rdacarrier
520 a Background: Studies identifying risk factors for death from breast cancer after ductal carcinoma in situ (DCIS) are rare. In this retrospective nested case-control study, clinicopathological factors in women treated for DCIS and who died from breast cancer were compared with those of patients with DCIS who were free from metastatic disease.Methods: The study included patients registered with DCIS without invasive carcinoma in Sweden between 1992 and 2012. This cohort was linked to the National Cause of Death Registry. Of 6964 women with DCIS, 96 were registered with breast cancer as cause of death (cases). For each case, up to four controls (318; women with DCIS, alive and without metastatic breast cancer at the time of death of the corresponding case) were selected randomly by incidence density sampling. Whole slides of tumour tissue were evaluated for DCIS grade, comedo necrosis, and intensity of periductal lymphocytic infiltrate. Composition of the immune cell infiltrate, expression of oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and proliferation marker Ki-67 were scored on tissue microarrays. Clinical information was obtained from medical records. Information on date, site, and histological characteristics of local and distant recurrences was obtained from medical records for both cases and controls.Results: Tumour tissue was analysed from 65 cases and 195 controls. Intense periductal lymphocytic infiltrate around DCIS was associated with an increased risk of later dying from breast cancer (OR 2.21. 95% c.i. 1.01 to 4.84). Tumours with more intense lymphocytic infiltrate had a lower T cell/B cell ratio. None of the other biomarkers correlated with increased risk of breast cancer death.Conclusion: The immune response to DCIS may influence the risk of dying from breast cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Wadsten, Charlottau Umeå universitet,Kirurgi,Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden4 aut0 (Swepub:umu)chwa0052
7001 a Acs, Balazsu Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Hartman, Johanu Karolinska Institutet4 aut
7001 a Fredriksson, Irmau Department of Breast Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Garmo, Hansu Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Translational Oncology and Urology Research, King's College London, London, United Kingdom4 aut
7001 a Wärnberg, Fredriku Department of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Sund, Malinu Umeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland4 aut0 (Swepub:umu)masu0021
7102 a Umeå universitetb Patologi4 org
7730 t British Journal of Surgeryd : Oxford University Pressg 111:2q 111:2x 0007-1323x 1365-2168
8564 u https://doi.org/10.1093/bjs/znae037y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1843862/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-221843
8564 8u https://doi.org/10.1093/bjs/znae037
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:238395442

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